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TranscriptomicsAnalysis of human healthy enteroids and colonoids (3D organoid models from small intestine and colon) exposed to chemotherapy agent Doxorubicin (DOX) sampled at four doses (1,10, 30 and 60uM) and three time points (24, 48 and 72h).
ADRs (adverse drug reactions) are one of the main reasons for treatment discontinuation or alterations in dose regimens in clinical settings. Chemotherapy-induced ADRs are common, especially gastrointestinal-induced ones. Within TransQST (transqst.org), one of the main goal is to improve the in vitr...
ORGANISM(S): Homo sapiens 
2022-01-27 | E-MTAB-11297 | biostudies-arrayexpress
TranscriptomicsAnalysis of human enteroids and colonoids (3D organoid models from small intestine and colon) exposed to chemotherapy agent 5-fluorouracil (5FU) in a dose-repeated exposure across three doses (10,100 and 1000uM) and sampled at three points (24, 48 and 72h) since initial exposure. Organoids were obtained from healthy human tissues.
ADRs (adverse drug reactions) are one of the main reasons for treatment discontinuation or alterations in dose regimens in clinical settings. Chemotherapy-induced ADRs are common, especially gastrointestinal-induced ones. Within TransQST (transqst.org), one of the main goal is to improve the in vitr...
ORGANISM(S): Homo sapiens 
2021-09-09 | E-MTAB-9134 | biostudies-arrayexpress
ModelsGall&Pin2022 - ODE model of the intestinal epithelium
We developed a compartmental model of the small intestinal epithelium that describes stem and progenitor cell proliferation and differentiation and cell migration onto the villus. The model includes a negative feedback loop from villus cells to regulate crypt proliferation and integrates heterogeneo...
2025-09-11 | MODEL2212120003 | BioModels
TransQST 
ProteomicsOcotea dataset project - UNIFAL
60 Ocotea crude plant extracts LC-HRMS/DIA-MSe metabolomics data
ORGANISM(S): Ocotea (ncbitaxon:63801) 
MSV000093006 | MassIVE
Proteomics6 Ocotea sp. dataset analyzed in DIA mode (ESI positive and negative)
This dataset consists of 6 Ocotea plant species analyzed in negative and positive modes, with data-independent acquisition (MSe), in a Waters Xevo G2 instrument. The available data were converted in .mzML format using the Waters2mzML software, available on Github. Detailed information about data a...
ORGANISM(S): Ocotea Lancifolia (ncbitaxon:881603) Ocotea Guianensis (ncbitaxon:128661) Ocotea Odorifera (ncbitaxon:128668) Ocotea Diospyrifolia (ncbitaxon:881600) Ocotea Porosa (ncbitaxon:1365881) Ocotea Notata 
2024-02-07 | MSV000094030 | MassIVE
TranscriptomicsMemory-like CD8 T-cells sustain the immune response to chronic viral infections.
We have discovered a small subpopulation of virus-specific CD8 T-cells that sustains the T-cell response in chronic infections. These cells are defined by - and depend on - the expression of the transcription factor Tcf1 (T cell factor 1) and show key characteristics of central memory cells while ...
ORGANISM(S): Mus musculus 
2016-08-22 | E-GEOD-83978 | biostudies-arrayexpress
TranscriptomicsRNA-seq of human colon biopsy tissue of healthy segments, from advanced breast cancer patients treated with capecitabine (5-FU)
ADRs (adverse drug reactions) are one of the main reasons for treatment discontinuation or alterations in dose regimens in clinical settings. Chemotherapy-induced ADRs are common, especially gastrointestinal-induced ones. Within TransQST (transqst.org), one of the main goal is to improve the in vitr...
ORGANISM(S): Homo sapiens 
2022-08-01 | E-MTAB-11295 | biostudies-arrayexpress
TranscriptomicsAnalysis of mouse healthy enteroids and colonoids (3D organoid models from small intestine and colon) exposed to chemotherapy agent Doxorubicin (DOX) sampled at four doses (0.1, 1, 10 and 30uM) and three time points (24, 48 and 72h).
ADRs (adverse drug reactions) are one of the main reasons for treatment discontinuation or alterations in dose regimens in clinical settings. Chemotherapy-induced ADRs are common, especially gastrointestinal-induced ones. Within TransQST (transqst.org), one of the main goal is to improve the in vitr...
ORGANISM(S): Mus musculus 
2022-12-31 | E-MTAB-11365 | biostudies-arrayexpress
TranscriptomicsNeuraminidase-exposed galactose promotes Streptococcus pneumoniae biofilm formation during colonization
Galactose promotes pneumococcal biofilms in vivo 15 mRNA profiles of Streptococcus pneumoniae samples that were grown under different conditions were generated using deep sequencing.
ORGANISM(S): Streptococcus pneumoniae 
2016-08-04 | E-GEOD-85196 | biostudies-arrayexpress
UnknownImpact of renal impairment on atrial fibrillation: ESC-EHRA EORP-AF Long-Term General Registry.
Not available
S-EPMC9287022 | biostudies-literature
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