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TranscriptomicsRNAseq of HCT116 p53KO cells transfected with either siRNA silencing ZNF84 or with negative control siRNA, in 2 variants of experiment a) with doxorubicin treatment (doxorubicin added 48h post-transfection, for the next 48h before harvesting) b) untreated, cultured 72h post-transfection
The aim of this experiments was to characterise the transcriptomic changes occurring in cancer cells, in which ZNF84 gene is silenced, in control conditions and when cells undergo stress by being treated with cytostatic doses of doxorubicin. We anticipated that ZNF84 regulates the level of p21 cell ...
ORGANISM(S): Homo sapiens 
2021-05-05 | E-MTAB-9848 | biostudies-arrayexpress
TranscriptomicsGene expression profile of sporadic and PSEN1 early-onset Alzheimer’s Disease
Alzheimer’s disease (AD) is the most common neurodegenerative dementia. Around 10% of cases present an age of onset before 65 years-old, which in turn can be divided in monogenic or familial AD (FAD) and sporadic early-onset AD (EOAD). Mutations in PSEN1, PSEN2 and APP genes have been linked with FA...
ORGANISM(S): Homo sapiens 
2015-01-20 | E-GEOD-39420 | biostudies-arrayexpress
GenomicsPancreatic islet epigenomics reveals enhancer clusters that are enriched in Type 2 diabetes risk variants
We combined ChIP-seq of chromatin marks and key islet transcription factor with RNA-seq in human islets to map cis-regulatory networks in this primary tissue. The output of this project provides a reference map to dissect genetic variants that alter the susceptibility for Type 2 diabetes, and assist...
ORGANISM(S): Homo sapiens 
2014-01-01 | E-MTAB-1919 | biostudies-arrayexpress
TranscriptomicsMultiple platform assessment of the EGF dependent transcriptome by microarray and deep tag sequencing analysis
Epidermal growth factor (EGF) is a key regulatory growth factor activating a myriad of processes affecting cell proliferation and survival that are relevant to normal development and disease. Here we have used a combined approach to study the EGF dependent transcriptome of HeLa cells. We obtained mR...
ORGANISM(S): Homo sapiens 
2011-07-18 | E-GEOD-17403 | biostudies-arrayexpress
ProteomicsChapter 3 - Anna Tribe - BCL6 is a context-dependent mediator of the glioblastoma therapy response
Whole proteome analysis of LN18 cell treated with one of five DNA-damaging treatments (fractionated irradiation (IRM), temozolomide (TMZ), acute irradiation 24 hours (IRS 24h), acute irradiation 48 hours (IRS 48h) or doxorubicin (Dox)) +/- the BCL6 inhibitor FX1.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000090274 | MassIVE
TranscriptomicsmiRNA-sequencing of human pancreatic islets and enriched beta-cells
Recent advances in the understanding of the genetics of type 2 diabetes (T2D) susceptibility have focused attention on the regulation of transcriptional activity within the pancreatic beta-cell. MicroRNAs (miRNAs) represent an important component of regulatory control, and have proven roles in the d...
ORGANISM(S): Homo sapiens 
2013-06-07 | E-GEOD-47720 | biostudies-arrayexpress
TranscriptomicsMC70 potentiates doxorubicin efficacy in colon and breast cancer in vitro treatment
A major limitation in the cancer treatment is the ability of cancer cells to become resistant to chemotherapeutic drugs, by multidrug establishment. Here, we evaluate the possibility to utilize MC70, either as ABC transporters inhibitor or as anticancer agent, in monotherapy or in combination with d...
ORGANISM(S): Homo sapiens 
2010-12-22 | E-GEOD-26250 | biostudies-arrayexpress
TranscriptomicsTime series of Balb/c spleen infected with Plasmodium yoelii non-lethal vs lethal strains
Knowledge on the dynamic features of the processes driven by malaria parasites in the spleen, our biggest lymphoid organ, is lacking. We have implemented intravital microscopy and magnetic resonance imaging of the mouse spleen in experimental infections with the Plasmodium yoelii non-lethal (17X) an...
ORGANISM(S): Mus musculus 
2010-10-12 | E-GEOD-17603 | biostudies-arrayexpress
TranscriptomicsMultiple platform assessment and isomir analysis of the EGF dependent microRNA-ome by microarray and deep sequencing analysis [small RNA-seq]
We have used an integrative high content analysis approach to identify the specific miRNAs implicated in EGF signaling in HeLa cells as potential mediators of cancer mediated functions. We have used microarray and deep-sequencing technologies in order to obtain a global view of the EGF miRNA transcr...
ORGANISM(S): Homo sapiens 
2013-06-11 | E-GEOD-41359 | biostudies-arrayexpress
TranscriptomicsMultiple platform assessment and isomir analysis of the EGF dependent microRNA-ome by microarray and deep sequencing analysis [Agilent]
We have used an integrative high content analysis approach to identify the specific miRNAs implicated in EGF signaling in HeLa cells as potential mediators of cancer mediated functions. We have used microarray and deep-sequencing technologies in order to obtain a global view of the EGF miRNA transcr...
ORGANISM(S): Homo sapiens 
2013-06-11 | E-GEOD-41181 | biostudies-arrayexpress
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