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ProteomicsFET fusion oncoproteins enrich SWI/SNF complex subtypes and interaction partners
• Abstract: FET fusion oncoproteins, containing the N-terminal of a FET protein (FUS, EWSR1 and TAF15) together with a DNA-binding transcription factor partner, are characteristic for around 20 different sarcomas and leukemias, including myxoid liposarcoma (MLS) and Ewing sarcoma (EWS). FET oncoprot...
ORGANISM(S): Homo sapiens (Human) 
2025-09-22 | PXD047503 | Pride
Myxoid liposarcoma Fet fusion oncoproteins Swi/snf chromatin remodeling complex Quantitative mass spectrometry Ewing sarcoma 
GenomicsSeclidemstat blocks the transcriptional function of multiple FET-fusion oncoproteins
Seclidemstat blocks the transcriptional function of multiple FET-fusion oncoproteins
PRJNA1111932 | ENA
ProteomicsIdentification of FET-oncoprotein-interacting proteins by immunoprecipitation and mass spectrometry analysis in sarcoma cell lines
The FET family of fusion oncogenes carry one of the three genes, FUS, EWSR1 or TAF15, as 5’‑partners juxtaposed to one of many different DNA binding transcription factor genes as 3’‑partners. FET fusion oncogenes are pathognomonic for many types of sarcoma and leukemia, such as FUS-DDIT3 in myxoid l...
ORGANISM(S): Homo sapiens (Human) 
2019-03-13 | PXD012680 | Pride
Sarcoma Lc-ms Immunoprecipitation Ft icr Orbitrap 
UnknownFET family fusion oncoproteins target the SWI/SNF chromatin remodeling complex.
Not available
S-EPMC6500973 | biostudies-literature
UnknownFET fusion oncoproteins interact with BRD4 and SWI/SNF chromatin remodelling complex subtypes in sarcoma.
Not available
S-EPMC9251840 | biostudies-literature
UnknownFET fusion oncoproteins enrich SWI/SNF complex subtypes and interaction partners.
Not available
S-EPMC12455829 | biostudies-literature
UnknownLoci-specific phase separation of FET fusion oncoproteins promotes gene transcription.
Not available
S-EPMC7935978 | biostudies-literature
TranscriptomicsSeclidemstat blocks the transcriptional function of multiple FET-fusion oncoproteins
Genes encoding the RNA-binding proteins FUS, EWSR1, and TAF15 (FET proteins) are involved in chromosomal translocations in several rare sarcomas. FET-rearranged sarcomas are often aggressive malignancies affecting pediatric, adolescent, and young and middle-aged adults, with prognosis depending on t...
ORGANISM(S): Homo sapiens 
2024-06-12 | GSE267611 | GEO
UnknownFET fusion oncoproteins disrupt physiologic DNA repair and create a targetable opportunity for ATR inhibitor therapy.
Not available
S-EPMC10187251 | biostudies-literature
UnknownFET fusion oncoproteins disrupt physiologic DNA repair networks and induce ATR synthetic lethality in cancer.
Not available
S-EPMC10312925 | biostudies-literature
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