Fetal cortex - OmicsDI

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biostudies-arrayexpress (303)
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Tissue

Brain (9)
Cell culture (5)
Cerebral cortex neuron (3)
Astrocyte (2)
Microglial cell (2)
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Anus (1)
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Bladder (1)
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Cerebral cortex (1)
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Esophagus (1)
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Fetus (1)
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Helper T-lymphocyte (1)
T-lymphocyte (1)

Disease

Normal (2)
Alzheimer's disease (2)
Transient gestational hypothyroxinemia and recovery of physiological levels of thyroid homone (1)
Transient gestational hyperthyroxinemia (1)
Transient gestational hypothyroxinemia (1)
Autoimmune disorder (1)
Adenoid cystic carcinoma (1)
Disease free (1)
Fetal alcohol syndrome (1)
Parkinson's disease (1)

Technology Type

Mass Spectrometry (16)
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Mass spectrometry (4)
Bottom-up proteomics (4)
Data-independent acquisition (3)
Gel-based experiment (2)
Top-down proteomics (2)
Illumina HiSeq 2500, ILLUMINA, Illumina HiSeq 2000 (1)
Affinity purification coupled with mass spectrometry proteomics (1)
Chemical cross-linking coupled with mass spectrometry proteomics (1)

Instrument Platform

Illumina NovaSeq 6000 (16)
Illumina HiSeq 2500 (8)
Illumina HiSeq 2000 (7)
Illumina HiSeq 4000 (6)
NextSeq 500 (4)
NextSeq 550 (3)
Single-Cell Extraction: For enzymatic digestion, pronase (Septomyces argeus, 1 mg/mL) was applied for 25 minutes at room temperature for P0 to P8 datasets. Cells were dissociated and triturated into a single-cell suspension in ACSF supplemented with 1% fetal calf serum (FCS) and DNase (1 µL/10 mL). Trituration was performed using three glass Pasteur pipettes of decreasing diameters. For P30 datasets, enzymatic digestion and cell dissociation were carried out using the Worthington Papain Dissociation System, following the manufacturer’s instructions. Single-Nuclei Extraction: For nuclei isolation, the Hibernate™-E Medium was removed, and 500 µL of chilled 0.1X NP40 Lysis Buffer was added. Tissue was homogenized using a Pellet Pestle (15 strokes) and incubated on ice for 5 minutes. The suspension was pipette-mixed 10 times using a wide-bore pipette tip and incubated for an additional 10 minutes on ice. Following lysis, 500 µL of chilled wash buffer was added, and the mixture was pipette-mixed 5 times using a regular-bore pipette tip. The suspension was filtered through a 30 µm cell strainer into a 50 mL tube to remove debris. The filtered suspension was transferred to a 1.5 mL tube and centrifuged at 950 × g for 10 minutes at 4°C. The supernatant was carefully removed, and the nuclei pellet was retained for downstream analysis. (2)
NextSeq 2000 (2)
DNBSEQ-G400 (2)
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Liquid Chromatography MS - negative - reverse phase (2)
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MS Imaging - (1)

Publication Date

2015 (49)
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2014 (42)
2013 (38)
2012 (28)
2026 (27)
2011 (24)
2022 (23)
2025 (22)
2010 (22)
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2008 (18)
2018 (13)
2009 (12)
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2023 (11)
2017 (11)
2019 (9)
2020 (8)
2007 (7)
2006 (3)
2005 (3)
2004 (1)

CHEBI ID

CHEBI:30915 (3)
CHEBI:15035 (2)
CHEBI:59270 (2)
CHEBI:68505 (2)
CHEBI:82942 (2)
CHEBI:34811 (2)
CHEBI:32389 (2)
CHEBI:82966 (2)
CHEBI:28733 (2)
CHEBI:72998 (2)
CHEBI:28238 (2)
CHEBI:19660 (2)
CHEBI:9907 (2)
CHEBI:26271 (2)
CHEBI:18132 (2)
CHEBI:27905 (2)
CHEBI:16750 (2)
CHEBI:6650 (2)
CHEBI:28683 (2)
CHEBI:74077 (2)
CHEBI:16566 (2)
CHEBI:15727 (2)
CHEBI:27823 (2)
CHEBI:17568 (2)
CHEBI:82914 (2)
CHEBI:15891 (2)
CHEBI:132983 (2)
CHEBI:24813 (2)
CHEBI:18012 (2)
CHEBI:16919 (2)

Metabolite Name

[2-(5,7-dihydroxy-4-oxo-2-phenyl-3,4-dihydro-2H-1-benzopyran-8-yl)-3,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxidanesulfonic acid (1)
H-89 (1)
PHENYL-gamma-Aminobutyric Acid (1)
DIHYDROROTENONE (1)
3-carboxy-4-methyl-5-(4-hydroxypentyl)-2-furanpropanoic acid (1)
9-PAHSA (1)
1-(s-glutathionyl)-2,4-dinitrobenzene (1)
Myristic Acid ethyl ester (1)
Triclosan sulfate (1)
Eicosapentaenoylcholine (1)
Benzoylcarnitine* (1)
Atazanavir (1)
20a-dihydroprogesterone (1)
N(8)-acetylspermidine (1)
Clopamide (1)
Palmitoleic Acid ethyl ester (1)
Estriol (1)
13-HpODE (1)
Stearic Acid ethyl ester (1)
Phytomonic Acid (1)
2-(Methylthio)ethanol (1)
Cyanidin 3-(2G-xylosylrutinoside) (1)
Citropten (1)
3-dehydrocholate (1)
4-hydroxy Nonenal Glutathione (1)
Testosterone sulfate (1)
¦Á-Ketoglutaric acid (1)
Cysteinylglycine disulfide* (1)
4-hydroxy-butyric acid (1)
7Z, 10Z, 13Z, 16Z, 19Z-docosapentaenoic acid (1)

First Public Date

2014 (25)
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2013 (4)

Study type

Transcription profiling by array (172)
RNA-seq of coding RNA (56)
RNA-seq of coding RNA from single cells (19)
ChIP-seq (12)
Methylation profiling by array (9)
Methylation profiling by high throughput sequencing (6)
ChIP-chip by tiling array (5)
Other (4)
Animal - High-throughput sequencing (3)
Comparative genomic hybridization by array (3)
RNA-seq of non coding RNA (3)
RNA-seq of total RNA (2)
Cell line - Single-cell sequencing (1)
Unknown experiment type (1)
Cell line - One-color microarray (1)
Proteomic profiling by mass spectrometer (1)
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Genotyping by array (1)
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ScATAC-seq (1)
DNA-seq (1)

Release Date

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2020 (67)
2015 (62)
2014 (62)
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2022 (55)
2016 (54)
2024 (48)
2013 (40)
2019 (39)
2018 (39)
2012 (37)
2011 (37)
2017 (34)
2010 (26)
2009 (23)
2008 (23)
2026 (12)
2007 (8)
2006 (5)
2004 (3)
2005 (2)
2002 (2)

Lab affiliation

DZNE Munich, Neuroproteomics, Feodor-Lynen-Str. 17, 81377 München, Germany (2)
Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, United States (1)
Department of Molecular Neurosciences, Center for Brain 1099 Research, Medical University of Vienna, Vienna, Austria (1)
Department of Pediatrics University of Maryland, School of Medicine (1)
Functional Proteomics Lab, National Center for Biotechnology (CNB-CSIC) (1)
Institute of Medical Sciences, University of Aberdeen, UK (1)
Lab of Neuroproteomics, Institute of Biology, Department of Biochemistry and Tissue Biology, University of Campinas (UNICAMP), Campinas, Brazil. (1)
Lehrstuhl für Neuroproteomik, Technische Universität München und Neuroproteomik, Deutsches Zentrum für Neurodegenerative Erkrankungen, München (1)
Max Planck Institute of Psychiatry Kraepelinstrasse 2 80804 Munich Germany (1)
Mount Sinai Hospital (Lab Head) (1)
Neurodegenerative Diseases Research Group, Korea Brain Research Institute (1)
Neurovirology group, Wuhan institute of Virology, Chinese Academy of Sciences (1)
Princess Margaret Hospital University of Toronto University Health Network (1)
Wellcome Trust Sanger Institute (1)
Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, CA, USA (1)

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Transcriptomics Responses to Hypoxia and Ketamine in Ovine Fetal Cerebral Cortex

Transient hypoxia in pregnancy stimulates a physiological reflex response that redistributes blood flow and defends oxygen delivery to the fetal brain. The chemoreceptor reflex that is responsible for this physiological response is dependent on glutamatergic neurotransmission which, in times of vig...

ORGANISM(S): Ovis aries

2016-04-06 | E-GEOD-76110 | biostudies-arrayexpress

Exposure to Propylthiouracil in Pregnant Mice Potentiates the Transcriptional Response to Thyroid Hormone in the Fetal Cerebral Cortex

Although the effects of thyroid hormones (TH) on the brain development have been extensively studied perinatally, effects of TH of maternal origin on the fetal brain development have been largely unexplored. We applied a high throughput study on the mouse models with aberrant TH levels on gestation ...

ORGANISM(S): Mus musculus

2014-02-04 | E-GEOD-43927 | biostudies-arrayexpress

Temporal Dynamics and Genetic Control of Transcription in the Human Prefrontal Cortex

In order to gain a global molecular perspective on how the human genome gives rise to the brain, we explore the temporal dynamics and genetic control of transcription in human dorsolateral prefrontal cortex in an extensive series of brain tissue from fetal development through aging. We discover a wa...

ORGANISM(S): Homo sapiens

2011-10-26 | E-GEOD-30272 | biostudies-arrayexpress

RNA-seq of human fetal brain cortex

The dataset contains RNA-seq for 32 human fetal brain cortex samples between 7 weeks post-conception (wpc) and 11.5 wpc and 14 control samples from different tissues across the same time frame. The study is designed with 8 fetal adrenal samples (4 of 46,XY; 4 of 46,XX) at 7wpc, 8wpc, 9wpc, 11.5wpc

ORGANISM(S): Homo sapiens

2025-04-05 | E-MTAB-13662 | biostudies-arrayexpress

Patterns of gene expression and evolution in the human developing cerebral cortex

The cerebral cortex underwent a rapid expansion and complexification during recent primate evolution, but the underlying developmental mechanisms remain essentially unknown. In order to uncover genetic networks underlying the development of the human cerebral cortex, we profiled the transcriptome o...

ORGANISM(S): Homo sapiens

2011-06-01 | E-GEOD-21858 | biostudies-arrayexpress

Developmental Regulation and Individual Differences of Neuronal Epigenomes in the Prefrontal Cortex

We report global distribution of trimethylated Histone H3 Lysine 4 (H3K4me3) in human prefrontal cortex neurons at different ages Neuronal nuclei from human prefrontal cortex were isolated by FACS. Regions marked by H3K4me3 were identified by chromatin immunoprecipiation followed by deep sequencing.

ORGANISM(S): Homo sapiens

2010-04-20 | E-GEOD-21172 | biostudies-arrayexpress

Single Cell Analysis Reveals Unexpected Transcriptional Heterogeneity of Neural Progenitors in the Developing Human Cortex

The human cerebral cortex depends for its normal development and size on a precisely controlled balance between self-renewal and differentiation of diverse neural progenitor cells. Specialized progenitors that are common in humans, but virtually absent in rodents, called â??outer radial gliaâ?? (ORG...

ORGANISM(S): Homo sapiens

2015-02-24 | E-GEOD-66217 | biostudies-arrayexpress

Transcription profiling of different regions of E16.5 mouse cerebral cortex to identify region- and layer-specific genes.

The mammalian neocortex develops layer organizations with regional differences represented by expression of multiple genes at embryonic stages. These genes could play important roles in the formation of areal cyto-architecture, yet, the number of genes identified so far is not sufficient to explain ...

ORGANISM(S): Mus musculus

2007-12-13 | E-GEOD-929 | biostudies-arrayexpress

Single-cell RNA-seq of mouse cerebral cortex

We have applied a recently developed, highly accurate and sensitive single-cell RNA-seq method (STRT/C1) to perform a molecular census of two regions of the mouse cerebral cortex: the somatosensory cortex and hippocampus CA1. We isolated cells fresh from somatosensory cortex (S1) and hippocampus CA1...

ORGANISM(S): Mus musculus

2015-02-20 | E-GEOD-60361 | biostudies-arrayexpress

RNA-seq of human fetal brain cortex

PRJEB71496 | ENA

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