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ProteomicsHuman fetal left and right frontal lobes LC-MSMS
Inherent hemispheric asymmetry is significant for cognition, language and other functions. An understanding of normal brain and asymmetry development in the early period will further the knowledge of how different hemispheres prioritize specific functions, which is still unknown. We analysed the dev...
ORGANISM(S): Homo sapiens (Human) 
2022-09-30 | PXD034192 | Pride
Fetal frontal lobe 
TranscriptomicsTissue-specific circular RNA induction during human fetal development
The pervasive expression of circular RNA from protein coding loci is a recently discovered feature of many eukaryotic gene expression programs. Computational methods to discover and quantify circular RNA are essential to the study of the mechanisms of circular RNA biogenesis and potential functiona...
ORGANISM(S): Homo sapiens 
2015-06-25 | E-GEOD-64283 | biostudies-arrayexpress
GenomicsWhole-genome analysis of 5-hydroxymethylcytosine and 5-methylcytosine at base resolution in the human brain
5-Hydroxymethylcytosine (hmC) is particularly abundant in mammalian brains with yetto be revealed functions. Here, we present genome-wide and single-base-resolutionmaps of hmC and mC in the human brain. We demonstrated that hmCs increasemarkedly from the fetal to the adult stage, and in the adult br...
ORGANISM(S): Homo sapiens 
2014-02-22 | E-GEOD-55249 | biostudies-arrayexpress
TranscriptomicsInduction of circular RNA in fetal heart development recapitulated in in vitro differentiation
We discovered induction of circular RNA in human fetal tissues, including the heart. In this study, we were able to recapitulate this induction by in vitro directed differentiation of hESCs to cardiomyocytes, paving the way for future studies into circular RNA regulation. We harvested hESCs at seque...
ORGANISM(S): Homo sapiens 
2015-06-25 | E-GEOD-64417 | biostudies-arrayexpress
TranscriptomicsA Cell Epigenotype Specific Model for the Correction of Cellular Heterogeneity in the Brain
Cellular heterogeneity may bias cell type specific epigenetic patterns leading to a dramatic increase in false positive or negative findings in psychiatric epigenetic studies. To address this issue, we performed fluorescence activated cell sorting (FACS) of neuronal nuclei in post mortem frontal cor...
ORGANISM(S): Homo sapiens 
2013-02-22 | E-GEOD-41826 | biostudies-arrayexpress
UnknownDifferential Early Mechanistic Frontal Lobe Responses to Choline Chloride and Soy Isoflavones in an Experimental Model of Fetal Alcohol Spectrum Disorder.
Not available
S-EPMC10145811 | biostudies-literature
UnknownAssessment of radial glia in the frontal lobe of fetuses with Down syndrome.
Not available
S-EPMC7441567 | biostudies-literature
TranscriptomicsTranscriptional termini of genes on chromosomes 21-22 (RNA mapping)
The purpose of these experiments was to determine the 5' and 3' transcriptional termini of genes on chromosomes 21-22. Towards this end, we mapped the poly A + RNA isolated from 12 normal tissues and four cell lines. For data usage terms and conditions, please refer to http://www.genome.gov/2752802...
ORGANISM(S): Homo sapiens 
2010-05-15 | E-GEOD-17358 | biostudies-arrayexpress
GenomicsH3K4me3 modification profiling of Huntingtons disease and control human post-mortem prefrontal cortex brain samples
Huntington’s disease (HD) is an autosomal-dominant neurodegenerative disorder resulting from expansion in the number of CAG repeats in the coding region of exon 1 of the Huntingtin (HTT) gene. One of the most widely studied chromatin modifications is trimethylated lysine 4 of histone 3 (H3K4me3). ...
ORGANISM(S): Homo sapiens 
2015-12-14 | E-GEOD-68952 | biostudies-arrayexpress
GenomicsWhole-genome analysis of 5-hydroxymethylcytosines and 5-methylcytosines at base resolution in human brain
5-hydroxymethylcytosines (5hmC) is particularly abundant in mammalian brain with little-known functions. Here we present the first genome-wide and single-base-resolution maps of 5hmC and 5mC in human brain by combined application of TAB-Seq and MethylC-Seq. We report that the majority of modified cy...
ORGANISM(S): Homo sapiens 
2014-02-14 | E-GEOD-46710 | biostudies-arrayexpress
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