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ProteomicsThe tumor suppressor Fhit in complex with the alarmone Ap3A binds to the ribosome and impedes translation
Upon cellular stress, the concentration of the alarmone diadenosine triphosphate (Ap3A) increases and is thought to trigger downstream adaptive processes. The known Ap3A-hydrolase fragile histidine triad (Fhit) is known to form a complex with Ap3A. The molecular mechanism of Fhit-Ap3A signaling is h...
ORGANISM(S): Homo sapiens (Human) 
2022-12-20 | PXD029645 | Pride
Ap-ms Mass spectrometry Ribosome Xl-ms Fhit Ap3a Translation 
GenomicsExpression data in Fhit-negative cell lines
Expression data in Fhit-negative cell lines
PRJNA555253 | ENA
TranscriptomicsExpression data in Fhit-negative cell lines
Characterizing signal pathway alterations that contribute to cellular transformation induced by loss of Fhit protein Abstract: The FHIT gene, encompassing an active common fragile site, FRA3B, is frequently silenced in preneoplasia and cancer, through gene rearrangement or methylation of regulatory ...
ORGANISM(S): Mus musculus 
2019-07-19 | GSE134478 | GEO
TranscriptomicsIdentification of transcriptional changes induced by FHIT in lung cancer cells NCI-H460
The FHIT gene, at 3p14.2, encompasses the common fragile site FRA3B and is frequently inactivated in primary tumors and cell lines of lung, head and neck, stomach, esophagus, cervix and breast cancer. In particular, loss of the FHIT protein is one of the most frequent alteration in lung tumors and p...
ORGANISM(S): Homo sapiens 
2008-12-25 | GSE11559 | GEO
UnknownFragile site orthologs FHIT/FRA3B and Fhit/Fra14A2: evolutionarily conserved but highly recombinogenic.
Not available
S-EPMC299872 | biostudies-literature
Genomics
Whole genome sequencing of mice with the human Fhit transgene and/or Fhit knockout
PRJNA776817 | ENA
UnknownGenetic, biochemical, and crystallographic characterization of Fhit-substrate complexes as the active signaling form of Fhit.
Not available
S-EPMC20403 | biostudies-literature
UnknownFhit tumor suppressor: guardian of the preneoplastic genome.
Not available
S-EPMC3400506 | biostudies-literature
UnknownIntegrated analysis of FHIT gene alterations in cancer.
Not available
S-EPMC11005815 | biostudies-literature
UnknownSequence conservation at human and mouse orthologous common fragile regions, FRA3B/FHIT and Fra14A2/Fhit.
Not available
S-EPMC33280 | biostudies-literature
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