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ProteomicsFibroblast-derived Smoothened governs prognosis of acute kidney injury
Although the tubule is the epicenter of damage, kidney fibroblast is increasingly appreciated in governing the prognosis of acute kidney injury (AKI). Smoothened (Smo), a heptahelical transmembrane protein, carries a hedgehog signal to mediate the communications between kidney fibroblasts and tubula...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2021-12-23 | MSV000088609 | MassIVE
ProteomicsElucidating Fibroblast Growth Factor-induced kinome dynamics using targeted mass spectrometry and dynamic modeling
Fibroblast growth factors (FGFs) are paracrine or endocrine signaling proteins that when activated by their ligands, can elicit a wide range of healthy and disease-related processes such as cell proliferation and the epithelial-to-mesenchymal transition (EMT). The detailed molecular pathway dynamics...
ORGANISM(S): Homo Sapiens 
PXD039005 | panorama
ProteomicsHuman Epididymis Protein 4 Promotes Aberrant Epithelial-Fibroblast Crosstalk in Pulmonary Fibrosis
Invasive lung myofibroblasts are the main cause of tissue remodeling in idiopathic pulmonary fibrosis (IPF). A key mechanism contributing to this important feature is aberrant crosstalk between the abnormal/injured lung epithelium and pulmonary fibroblasts. Here, we demonstrated that lungs from pati...
ORGANISM(S): Homo Sapiens 
2024-12-17 | PXD058959 |
ProteomicsCharacterization of various cell lines from different ampullary cancer subtypes and cancer associated fibroblast-mediated responses
Introduction: Ampullary cancer is a relatively rare entity and usually treated by pancreatoduodenectomy followed by adjuvant therapy. The intestinal subtype is associated with markedly improved prognosis after resection. Only few cell lines are available for in vitro studies of ampullary cancer and ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080802 | MassIVE
ProteomicsHypoxia-induced changes in the fibroblast secretome, exosome, and whole-cell proteome using cultured, cardiac-derived cells isolated from neonatal mice
Dataset Pertaining to the proteome changes of the cardiac fibroblast in the whole cell, exosome, and soluble secretome.
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2016-08-12 | MSV000080038 | MassIVE
ProteomicsThe proteomic study of serially passaged human skin fibroblast cells uncovers down-regulation of SMC4 involved in replicative senescence
In this study, a label-free quantitative proteomic approach was employed to analyze the serial passaged human skin fibroblast （CCD-1079Sk） cells, within 3305 proteins quantified. Of which, 372 proteins were significantly changed in early passage(P6), middle passage (P12) and later passage (P21), wit...
ORGANISM(S): Homo sapiens (Human) Acyrthosiphon pisum (Pea aphid) 
2018-10-22 | PXD007732 | Pride
Proteomic study  human skin fibroblasts  serially passaged  replicative senescence  smc4 
Proteomicsintercardiac Phosphoproteome/proteome regulation of cardiomyocyte-fibroblast signaling
Secretome-mediated signaling from human iPSC-derived cardiomyocytes (TGF-beta induced dysfunction) to primary human cardiac fibroblasts was investigated to identify downstream regulators of fibrosis. Quantitative proteomic profiling revealed a dynamic reprogramming of fibroblast global proteome, wit...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-06-27 | MSV000092293 | MassIVE
ProteomicsProteomic analysis of 3T3 murine fibroblast used as feeder-layer
3T3 murine embryonic fibroblasts are used as feeder layers to support the proliferative potential of human primary keratinocytes during in vitro expansion for cell and gene therapy applications. To identify signals mediating this function, we analyzed fibroblast protein content using mass spectromet...
ORGANISM(S): Mus musculus (Mouse) 
2026-05-18 | PXD078052 | Pride
Feeder-layer Fibroblast Skin expansion 
ProteomicsThe role of GATD3A in regulating Fibroblast-like synoviocytes functions
The role of GATD3A (glutamine amidotransferase-like class 1 domain-containing 3A) in regulating functions of fibroblast-like synoviocytes was assessed by lentivirus infection and label-free proteomics assay.
ORGANISM(S): Homo Sapiens 
2024-08-30 | PXD055034 |
UnknownElucidating Fibroblast Growth Factor-Induced Kinome Dynamics Using Targeted Mass Spectrometry and Dynamic Modeling.
Not available
S-EPMC10368922 | biostudies-literature
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