Sort   by:  
 Page size 
MetabolomicsEnterotoxigenic Bacteroides fragilis exacerbates alcoholic liver disease progression through kynurenine mediated AMPK signaling inhibition and retinoic acid depletion

Abstract Background & Aims: Alcoholic liver disease (ALD) pathogenesis involves gut microbiota dysbiosis, but specific pathobionts and mechanisms remain unclear. This study investigated the role of patient-derived enterotoxigenic Bacteroides fragilis (ETBF) in ALD progression and its underlyi...

2026-09-07 | MTBLS15572 | MetaboLights
ProteomicsO-GlcNAcylation controls pro-fibrotic transcriptional regulatory signaling in hepatic stellate cells
Liver injury causes “transdifferentiation” of quiescent hepatic stellate cells (Q-HSCs) into wound repairing myofibroblasts (MF-HSCs), whose uncontrolled activation leads ultimately to liver fibrosis. Although this process is triggered by deep metabolic and transcriptional reprogramming, functional ...
ORGANISM(S): Homo sapiens (Human) 
2024-05-21 | PXD045860 | Pride
Fibrogenic liver injuries Human O-linked β d n acetylglucosaminylation 
Transcriptomicsc-Met confers protection against chronic liver tissue damage and fibrosis progression after bile-duct-ligation in mice
The HGF/c-Met system is an essential inducer of hepatocyte growth and proliferation. Although a fundamental role for the HGF receptor c-Met has been demonstrated in acute liver regeneration its cell specific role in hepatocytes during chronic liver injury and fibrosis progression has not been determ...
ORGANISM(S): Mus musculus 
2009-02-18 | E-GEOD-13992 | biostudies-arrayexpress
TranscriptomicsTranscriptomic signatures of progressive and regressive liver fibrosis and portal hypertension
Persistent liver injury triggers a fibrogenic program that causes pathologic remodelling of the hepatic microenvironment (i.e., liver fibrosis) and portal hypertension. The dynamics of gene regulation during liver disease progression and regression remain understudied. Here, we generated hepatic tra...
ORGANISM(S): Mus musculus 
2024-02-13 | E-MTAB-13804 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat liver after Ghrelin treatment and bile duct ligation
Hepatic fibrosis, the wound-healing response to repeated liver injury, ultimately leads to cirrhosis. There is an urgent need to develop effective antifibrotic therapies. Ghrelin (encoded by Ghrl) is an orexigenic hormone that has pleiotrophic functions including protection against cell death1. Here...
ORGANISM(S): Rattus norvegicus 
2009-01-13 | E-GEOD-13747 | biostudies-arrayexpress
TranscriptomicsLoss of HGF/c-Met signaling in hepatocytes leads to disruption of the hepatic microenvironment and aggravates the progression of chronic liver fibrosis
Background: HGF/c-Met signaling plays a pivotal role in hepatocyte survival and tissue remodeling during liver regeneration. Treatment with HGF has been shown to accelerate resolution of fibrotic liver lesions in experimental animal models. To formally address the importance of c-Met signaling in he...
ORGANISM(S): Mus musculus 
2011-11-09 | E-GEOD-25583 | biostudies-arrayexpress
TranscriptomicsIntegrative gene expression profiling analysis of human quiescent hepatic stellate cells
Unveiling the regulatory pathways maintaining hepatic stellate cells (HSC) in a quiescent (q) phenotype is essential to develop new therapeutic strategies to treat fibrogenic diseases. To uncover the miRNA-mRNAs regulatory interactions in qHSCs, HSCs were FACS-sorted from healthy livers and activate...
ORGANISM(S): Homo sapiens 
2015-11-23 | E-GEOD-67664 | biostudies-arrayexpress
UnknownTgfb3 and Mmp13 regulated the initiation of liver fibrosis progression as dynamic network biomarkers.
Not available
S-EPMC7812286 | biostudies-literature
UnknownHepatic stellate cell single cell atlas reveals a highly similar activation process across liver disease aetiologies.
Not available
S-EPMC11699746 | biostudies-literature
UnknownMyofibroblast-specific YY1 promotes liver fibrosis.
Not available
S-EPMC7134377 | biostudies-literature
Sort   by:  
 Page size