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TranscriptomicsGENOMIC ANALYSIS OF FIBROLAMELLAR HEPATOCELLULAR CARCINOMA REVEALS A UNIQUE MOLECULAR PROFILE
Fibrolamellar hepatocellular carcinoma (FLC) is a rare primary hepatic cancer usually developed in non-cirrhotic livers of children and young adults with unknown etiology. Treatment is limited to surgical intervention. To date, molecular pathogenesis of FLC has been poorly characterized. A cohort of...
ORGANISM(S): Homo sapiens 
2015-02-12 | E-GEOD-59443 | biostudies-arrayexpress
TranscriptomicsGenomic analysis of Fibrolammellar Hepatocellular Carcinoma reveals an unique molecular profile [Test set]
Background & Aims: Fibrolamellar hepatocellular carcinoma (FLC) is a rare primary hepatic cancer usually developed in non-cirrhotic livers of children and young adults with unknown etiology. Treatment is limited to surgical intervention. To date, molecular pathogenesis of FLC has been poorly char...
ORGANISM(S): Homo sapiens 
2015-02-12 | E-GEOD-57726 | biostudies-arrayexpress
TranscriptomicsGenomic analysis of Fibrolammellar Hepatocellular Carcinoma reveals an unique molecular profile [Training set]
Background & Aims: Fibrolamellar hepatocellular carcinoma (FLC) is a rare primary hepatic cancer usually developed in non-cirrhotic livers of children and young adults with unknown etiology. Treatment is limited to surgical intervention. To date, molecular pathogenesis of FLC has been poorly char...
ORGANISM(S): Homo sapiens 
2015-02-12 | E-GEOD-57725 | biostudies-arrayexpress
ProteomicsDisruption of proteome by an oncogenic fusion kinase alters metabolism in fibrolamellar hepatocellular carcinoma
Fibrolamellar hepatocellular carcinoma (FLC) is a usually lethal primary liver cancer driven by a somatic dysregulation of protein kinase A. We show that the proteome of FLC tumors is distinct from that of adjacent nontransformed tissue. These changes can account for some of the cell biological and ...
ORGANISM(S): Homo sapiens (Human) 
2024-10-17 | PXD046905 | Pride
Proteomics Fibrolamellar hepatocellular carcinoma Flc 
TranscriptomicsTranscription profiling by array of Pure Fibrolamellar Hepatocellular carcinoma
A Cartes d'Identite des Tumeurs (CIT) project from the french Ligue Nationale Contre le Cancer (http://cit.ligue-cancer.net) | Affymetrix HG-U133 Plus 2.0 : 5 mixed fibrolamellar carcinoma (m-FLC), 17 pure fibrolamellar carcinoma (p-FLC), 7 hepatocelluar carcinoma arising in non-cirrhotic liver (nc...
ORGANISM(S): Homo sapiens 
2014-08-15 | E-MTAB-1503 | biostudies-arrayexpress
GenomicThe Genome and Transcriptome of Fibrolamellar Hepatocellular Carcinoma

Fibrolamellar hepatocellular carcinoma (FL-HCC) is a rare liver tumor primarily affecting adolescents and young adults. Little is known of the molecular pathogenesis. To characterize the disease we performed RNA sequencing and whole genome sequencing on FL-HCC tumors and adjacent normal tissue. T...

phs000709 | dbGaP
ProteomicsThe oncogenic fusion protein DNAJB1-PRKACA can be specifically targeted by peptide-based immunotherapy in fibrolamellar hepatocellular carcinoma
The DNAJB1-PRKACA fusion transcript is the oncogenic driver in fibrolamellar hepatocellular carcinoma, a lethal disease lacking specific therapies. This study reports on the identification, characterization, and immunotherapeutic application of HLA-presented neoantigens specific for the DNAJB1-PRKAC...
ORGANISM(S): Homo sapiens (Human) 
2022-10-13 | PXD029882 | Pride
Cancer Hla ligands Mass spectrometry Fibrolamellar hepatocellular carcinoma Immunopeptidomics Fl-hcc 
TranscriptomicsCIT-CHEF
Fibrolamellar hepatocellular carcinoma (FLC) is a rare type of primary liver cancer that often arises in children, adolescents and young adults. At the pathological level, FLC display pure morphology or can present with mixed morphology involving a conventional HCC component. Owing to the rarity of ...
ORGANISM(S): Homo sapiens 
2015-06-15 | E-MTAB-2675 | biostudies-arrayexpress
GenomicsGENOMIC ANALYSIS OF FIBROLAMELLAR HEPATOCELLULAR CARCINOMA
GENOMIC ANALYSIS OF FIBROLAMELLAR HEPATOCELLULAR CARCINOMA REVEALS A UNIQUE MOLECULAR PROFILE
PRJEB7902 | ENA
TranscriptomicsGenomic analysis of Fibrolammellar Hepatocellular Carcinoma reveals an unique molecular profile.
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2015-02-12 | E-GEOD-57727 | biostudies-arrayexpress
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