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GenomicsGenome profiling of fibrolamellar carcinoma [CGH]
Fibrolamellar hepatocellular carcinoma (FL-HCC) is a rare variant of HCC that most frequently affects young adults. Because of its rarity and an absence of preclinical models, the molecular biology of FL-HCC remains unclear. Our objective was to analyze chromosomal alterations and dysregulated gene ...
ORGANISM(S): Homo sapiens 
2017-06-09 | GSE64103 | GEO
TranscriptomicsGenome and transcriptome profiling of fibrolamellar carcinoma [RNA-Seq]
Fibrolamellar hepatocellular carcinoma (FL-HCC) is a rare variant of HCC that most frequently affects young adults. Because of its rarity and an absence of preclinical models, the molecular biology of FL-HCC remains unclear. Our objective was to analyze chromosomal alterations and dysregulated gene ...
ORGANISM(S): Homo sapiens 
2017-06-09 | GSE63018 | GEO
TranscriptomicsRNA-sequencing analysis of human fibrolamellar hepatocellular carcinoma and 4 maturational stages of the human hepatobiliary system
The etiology of fibrolamellar hepatocellular carcinoma (FL-HCC), a liver cancer occurring increasingly in children to young adults, is poorly understood. We performed high-throughput sequencing on mRNA isolated from a newly developed model of FL-HCC and 4 different maturational lineages of the hepat...
ORGANISM(S): Homo sapiens 
2015-10-06 | GSE73114 | GEO
ProteomicsComprehensive proteometics identifies FBXL6 substrates involved in liver cancer
FBXL6 is frequently over-expressed in human hepatocellular carcinoma (HCC). However, it is still unknown the underlying mechanisms by which FBXL6 promotes HCC. In this study, we compared ubiquitinated protein profiles among a panel of liver tissue samples (including HCC, adjacent tissues and normal...
ORGANISM(S): Mus musculus (Mouse) 
2024-01-26 | PXD032357 | Pride
Hcc Mice Fbxl6 
TranscriptomicsDNA methylation activated full-length EMX1 facilitates metastasis through EMX1-EGFR-ERK axis in hepatocellular carcinoma
Altered DNA methylation is a crucial epigenetic event in hepatocellular carcinoma (HCC) development and progression. Through methylation-transcriptomic analysis, we identified a set of sixty potential DNA methylation-based epidriver genes. This set of genes focuses on the hypermethylation of EMX1, w...
ORGANISM(S): Homo sapiens 
2023-11-29 | GSE245505 | GEO
GenomicThe Genome and Transcriptome of Fibrolamellar Hepatocellular Carcinoma

Fibrolamellar hepatocellular carcinoma (FL-HCC) is a rare liver tumor primarily affecting adolescents and young adults. Little is known of the molecular pathogenesis. To characterize the disease we performed RNA sequencing and whole genome sequencing on FL-HCC tumors and adjacent normal tissue. T...

phs000709 | dbGaP
TranscriptomicsThe potential biomarkers for HCC patients with functional loss of both p53 and Tsc1
p53 mutations occur frequently in human hepatocellular carcinoma (HCC). Activation of the mammalian target of rapamycin (mTOR) pathway is also associated with HCC. However, it is still unknown whether these changes together initiate HCC and can be targeted as a potential therapeutic strategy. Here, ...
ORGANISM(S): Mus musculus 
2021-08-30 | GSE153223 | GEO
TranscriptomicsSingle cell RNA-seq and TCR-seq of T cell responses against DNAJB1-PRKACA
The DNAJB1-PRKACA fusion transcript is the oncogenic driver in fibrolamellar hepatocellular carcinoma (FL-HCC), a lethal disease lacking specific therapies. Here, we report on the identification, characterization and first immunotherapeutic application of HLA-presented neoantigens specific for the D...
ORGANISM(S): Homo sapiens 
2022-09-12 | GSE210337 | GEO
TranscriptomicsTranscriptome sequencing of tumor associated macrophages cells in HCC liver of OXCT1mKO mice.
6-8 weeks male LysCre/+ OXCT1fl/fl (OXCT1mKO or mKO for short) and its littermates Lys+/+ OXCT1fl/fl (control or ctrl) mice were used to build HCC implantation model (Hep1-6 in Portal Vein injection). RNA was extracted from tumor associated macrophages of OXCT1mKO and their littermate control mice f...
ORGANISM(S): Mus musculus 
2024-07-21 | GSE237917 | GEO
UnknownTreatment and Prognosis of Fibrolamellar Hepatocellular Carcinoma: a Systematic Review of the Recent Literature and Meta-analysis.
Not available
S-EPMC10073062 | biostudies-literature
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