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TranscriptomicsTranscription profiling of hippocampus and retina from two rare inbred mouse models of accelerated neurological senescence ( SAMP8 and SAMP10) and a related wild type strain SAMR1 to study molecular senescence of the retina and hippocampus.
Background: Progressive neurological dysfunction is a key aspect of human aging. Because of underlying differences in the aging of mice and humans, useful mouse models have been difficult to obtain and study. We have used gene-expression analysis and polymorphism screening to study molecular senesce...
ORGANISM(S): Mus musculus 
2007-11-14 | E-GEOD-6238 | biostudies-arrayexpress
GenomicsMaternal Influence on Exonic CpG Island Methylation in the Developing Hippocampus [Bisulfite-Seq]
Maternal 5-HT1A-receptor (R) is required for the timely development of the hippocampus and the establishment of emotional behaviors in Swiss-Webster (SW) mice. A partial and/or complete loss of maternal 5-HT1AR results in delayed ventral dentate granule cell (v-DGC) development and subsequent anxie...
ORGANISM(S): Mus musculus 
2013-02-04 | E-GEOD-35854 | biostudies-arrayexpress
Other,MultiomicsChevrette et al 2019 Insect-associated Streptomyces
Paper title: The antimicrobial potential of Streptomyces from insect microbiomes. Author list: Chevrette MG, Carlson CM, Ortega HE, Thomas C, Ananiev GE, Barns KJ, Book AJ, Cagnazzo J, Carlos C, Flanigan W, Grubbs KJ, Horn HA, Hoffmann FM, Klassen JL, Knack JJ, Lewin GR, McDonald BR, Muller L, Melo ...
ORGANISM(S): Pseudonocardia Kitasatospora Streptomyces Gordonia <actinomycete> 
2019-12-18 | MSV000084723 | MassIVE
ProteomicsMulti-Omic Evidence of Brain Region Specific APOE Genotype Perturbations in Alzheimer's Disease
Simultaneous extraction of proteins and lipids from human frontal cortex and cerebellum brain tissue was performed using the MPLEx procedure for both control and Alzheimer's disease patients. The isolated proteins were then reduced, alkylated, tryptically digested and evaluated with LC-IMS-MS. The p...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-08-08 | MSV000092627 | MassIVE
MetabolomicsGNPS - From plants to ants: Evaluating lipidomic changes in leaf-cutter ant fungus gardens
Leaf-cutter ants use fresh plant material to cultivate an obligate mutualistic fungus Leucoagaricus gongylophorus in specialized fungus gardens to access and transform nutrients from plant biomass that would otherwise be unavailable to the ants. Here, we evaluated the lipidomic differences between t...
ORGANISM(S): Environmental Samples <bacteria> (ncbitaxon:48479) 
2019-10-30 | MSV000084520 | GNPS
TranscriptomicsMaternal Influence on Exonic CpG Island Methylation in the Developing Hippocampus
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2013-02-04 | E-GEOD-35856 | biostudies-arrayexpress
TranscriptomicsTranscriptome In Vivo Analysis (TIVA) of spatially defined single cells in intact live mouse and human brain tissue
Transcriptome profiling is an indispensable tool in advancing the understanding of single cell biology, but depends upon methods capable of isolating mRNA at the spatial resolution of a single cell. Current capture methods lack sufficient spatial resolution to isolate mRNA from individual in vivo re...
ORGANISM(S): Mus musculus 
2014-01-12 | E-GEOD-52525 | biostudies-arrayexpress
TranscriptomicsCulture media-induced transcriptional variation in lung cancer (A549), colorectal cancer (HCT116), ovarium cancer (SKOV3) and glioblastoma (U87MG) spheroids
Spheroids, near spherical multicellular aggregates, are one of the most common types of threedimensional (3D) cell cultures. Despite decades of implementation of spheroid technology in various fields of life science and medical research, no minimal information (MI) guidelines are available to cope w...
ORGANISM(S): Homo sapiens 
2021-10-01 | E-MTAB-10862 | biostudies-arrayexpress
TranscriptomicsAntenatal Blood DNA Methylation Profiles
DNA methylation profiles were generating using Illumina HM450 microarrays in a prospective sample blood from the prenatal period of pregnant mood disorder patients who would and would not develop depression post partum. We recruited 54 pregnant women with a history of either Major Depression or Bipo...
ORGANISM(S): Homo sapiens 
2013-05-24 | E-GEOD-44132 | biostudies-arrayexpress
TranscriptomicsGene expression profiling in acute murine autoimmune hepatitis
The etiology of autoimmune hepatitis is poorly understood but likely involves Th1 cells producing IFN-γ. BALB/c background TGF-β1-/- mice rapidly develop fulminant Th1-mediated autoimmune hepatitis. Our aims are to profile liver gene expression in TGF-β1-/- mice, to identify gene expression pathways...
ORGANISM(S): Mus musculus 
2009-02-28 | E-GEOD-9892 | biostudies-arrayexpress
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