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GenomicsIdh1-R132H mutation increases murine hematopoietic progenitors and alters epigenetics.
Mutations in the IDH1 and IDH2 genes encoding isocitrate dehydrogenases are frequent in human glioblastomas1 and cytogenetically normal acute myeloid leukemias (AML)2. These alterations are gain-of-function mutations in that they drive the synthesis of the M-bM-^@M-^\oncometaboliteM-bM-^@M-^] R-2-hy...
ORGANISM(S): Mus musculus 
2012-07-22 | E-GEOD-38687 | biostudies-arrayexpress
TranscriptomicsLeukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation
Cancer-associated IDH mutations are characterized by neomorphic enzyme activity and resultant 2 hydroxyglutarate (2HG) production. Mutational and epigenetic profiling of a large AML patient cohort revealed that IDH1/2-mutant AMLs display global DNA hypermethylation and a specific hypermethylation si...
ORGANISM(S): Homo sapiens 
2010-12-03 | E-GEOD-24505 | biostudies-arrayexpress
UnknownCoenzyme M: An Archaeal Antioxidant as an Agricultural Biostimulant.
Not available
S-EPMC11851959 | biostudies-literature
GenomicsMaternal Influence on Exonic CpG Island Methylation in the Developing Hippocampus [Bisulfite-Seq]
Maternal 5-HT1A-receptor (R) is required for the timely development of the hippocampus and the establishment of emotional behaviors in Swiss-Webster (SW) mice. A partial and/or complete loss of maternal 5-HT1AR results in delayed ventral dentate granule cell (v-DGC) development and subsequent anxie...
ORGANISM(S): Mus musculus 
2013-02-04 | E-GEOD-35854 | biostudies-arrayexpress
UnknownGlobal REACH: Assessment of Brady-Arrhythmias in Andeans and Lowlanders During Apnea at 4330 m.
Not available
S-EPMC6987448 | biostudies-literature
UnknownMutations in the anti-sigma H factor RshA confer resistance to econazole and clotrimazole in Mycobacterium smegmatis.
Not available
S-EPMC7491931 | biostudies-literature
UnknownMolecular-Scale Insights into the Heterogeneous Interactions between an <i>m</i>-Terphenyl Isocyanide Ligand and Noble Metal Nanoparticles.
Not available
S-EPMC11803716 | biostudies-literature
GenomicsGenome-wide maps of DNA cytosine methylation state in during normal differentiation commitment in hematopoietic stem cells (HSC) and in Special AT-rich sequence-binding protein1 (Satb1) - deficient HSC
Our data show Satb1 deficiency leads to alterations in DNA cytosine methylation and a commitment-primed epigenetic state in HSCs. Examination of DNA cytosine methylation in wild type HSC and differentiation-committed progenitors as well as in wild type HSC and HSC lacking Satb1 (n=2 each).
ORGANISM(S): Mus musculus 
2013-04-07 | E-GEOD-44304 | biostudies-arrayexpress
UnknownAnalytical considerations associated with implementing M2+ correction factors to address false positives on As and Se within U.S. EPA method 200.8.
Not available
S-EPMC7147816 | biostudies-literature
UnknownValidation of the Multidimensional Sociosexual Orientation Inventory (SOI-M) in the Chilean population
Not available
S-EPMC12352763 | biostudies-literature
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