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MetabolomicsF-actin dynamics couples sphingolipid metabolism to epithelial barrier integrity in chronic colitis
Intestinal barrier dysfunction is a hallmark of gastrointestinal disorders, including inflammatory bowel diseases (IBD). In IBD, the disruption of the gut barrier causes liquid loss and persistent immune response. Understanding the cellular events underlying epithelial barrier disruption during chro...
2026-04-01 | MTBLS14166 | MetaboLights
Proteomicsstudy of actin interactome in Alzheimers disease mouse model
Filamentous actin (F-actin) is one of the major cytoskeleton proteins present in dendritic spines and it is an essential component for defining dendritic spine morphology. We have shown that synaptosomal F-actin levels were significantly decreased in APP/PS1 mice as early as one month of age. The mo...
ORGANISM(S): Mus musculus (Mouse) 
2024-10-17 | PXD050802 | Pride
F-actin loss Alzheimers disease Synapse 
ProteomicsIdentification of Actin Filament Interactors in Giardia lamblia
The deep-branching protozoan parasite Giardia lamblia is the causative agent of the intestinal disease giardiasis. Consistent with its proposed evolutionary position, many pathways are minimalistic or divergent, including its actin cytoskeleton. Giardia is the only eukaryote known to lack all canoni...
ORGANISM(S): Giardia lamblia ATCC 50803 
2021-07-10 | PXD026067 | Pride
Actin Giardia 
UnknownMultiple functions for actin during filamentous growth of Saccharomyces cerevisiae.
Not available
S-EPMC25429 | biostudies-literature
UnknownFunctional characterisation of filamentous actin probe expression in neuronal cells.
Not available
S-EPMC5690639 | biostudies-literature
UnknownArf6 Regulates Endocytosis and Angiogenesis by Promoting Filamentous Actin Assembly.
Not available
S-EPMC9980066 | biostudies-literature
UnknownDynamics of Actin Cables in Polarized Growth of the Filamentous Fungus Aspergillus nidulans.
Not available
S-EPMC4860496 | biostudies-literature
UnknownFilamentous-Actin-Mimicking Nanoplatform for Enhanced Cytosolic Protein Delivery.
Not available
S-EPMC10933650 | biostudies-literature
UnknownCapillary pericytes express α-smooth muscle actin, which requires prevention of filamentous-actin depolymerization for detection.
Not available
S-EPMC5862523 | biostudies-literature
ProteomicsDownstream targets of Ca2+ signals in filamentous fungi
Ca2+ is a second messenger that regulates a variety of cellular responses in fungi. However, the mechanism behind how Ca2+ signals are transmitted within the cell as they regulate downstream targets remains unclear. We used a fluorescent Ca2+ biosensor to visualize the changes in Ca2+ concentration ...
ORGANISM(S): Cellular Organisms 
2022-09-08 | PXD027777 | JPOST Repository
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