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TranscriptomicsTranscription profiling of mouse model of Wilson disease reveals specific changes of liver transcriptome in the early stages of copper accumulation
Wilson disease (WD) is a severe metabolic disorder caused by genetic inactivation of copper-transporting ATPase ATP7B. In WD, copper accumulates in several tissues, particularly in the liver, inducing marked time-dependent pathological changes. To identify initial events in the copper-dependent de...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-5348 | biostudies-arrayexpress
TranscriptomicsTRANSCRIPTIONAL REMODELLING IN RESPONSE TO CHANGING COPPER LEVELS IN WILSON DISEASE MODEL OF SACCHAROMYCES CEREVISIAE
A 3 x 2 factorial design was used to elucidate the genome-wide transcriptional response to the deletion of yeast ortholog of Wilson and Menkes disease causing gene; CCC2, at changing copper levels. Homozygous deletion mutant of CCC2, which encodes Cu+2 transporting P-type ATPase required to export c...
ORGANISM(S): Saccharomyces cerevisiae 
2013-09-02 | E-MEXP-3927 | biostudies-arrayexpress
GenomicsImputation analysis file
This data set includes the following summary level data file used for the imputation data: imputation.sv.assoc.txt: results from single variant association analysis in imputed samples
EGAD00010001184 | EGA
GenomicsExome chip analysis file
This data set includes the following summary level data file used for the exome chip analysis: exome_chip.sv.assoc.txt: results from single variant association analysis in exome chip
EGAD00010001187 | EGA
TranscriptomicsTargets of the transcription factor Brachyury in differentiating mouse ES cells
Brachyury (or T) is expressed in the primitive streak, tailbud and notochord of the early mouse embryo (Herrmann et al., 1990; Wilkinson et al., 1990). It plays a key role in early development: mouse embryos lacking functional Brachyury protein fail to gastrulate properly, do not form a differentiat...
ORGANISM(S): Mus musculus 
2012-05-28 | E-GEOD-16646 | biostudies-arrayexpress
GenomicsComparative epigenomic analysis of JUN, H3K27ac, H3K4me3 and H3K4me2 in primary aortic endothelial cells
This accession ID containes ChIP-seq data for JUN, H3K27ac, H3K4me3 and H3K4me2 in primary aortic endothelial cells. This data will be used for: 1) A phylogenetic framework for comparative analysis of chromatin state in mammalian species. Sara Knaack, Lina Antounians, Azad Alizada, Alejandra Medina...
ORGANISM(S): Rattus norvegicus 
2025-06-19 | E-MTAB-14612 | biostudies-arrayexpress
TranscriptomicsTranscriptome Analysis of Human Diabetic Kidney Disease
This SuperSeries is composed of the following subset Series: GSE30528: Transcriptome Analysis of Human Diabetic Kidney Disease (DKD Glomeruli vs. Control Glomeruli) GSE30529: Transcriptome Analysis of Human Diabetic Kidney Disease (DKD Tubuli vs. Control Tubuli) GSE30566: Transcriptome Analysis of H...
ORGANISM(S): Homo sapiens 
2011-08-02 | E-GEOD-30122 | biostudies-arrayexpress
TranscriptomicsTranscriptome Analysis of Human Diabetic Kidney Disease (Control Glomeruli vs. Control Tubuli)
We identified 1,700 differentially expressed probesets in DKD glomeruli and 1,831 in diabetic tubuli; 330 probesets were commonly differentially expressed in both compartments. The canonical complement signaling pathway was determined to be statistically differentially regulated in both DKD glomerul...
ORGANISM(S): Homo sapiens 
2011-08-02 | E-GEOD-30566 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of Kidney Glomeruli from Type 2 diabetic (db/db) and non-diabetic mice
We investigated the gene expression profiles of RNA isolated from kidney glomeruli from aged, 25 week old type-2 diabetic (db/db) and non-diabetic mice. In order to investigate the consequences of hyperglycemia on the pathogenesis and progression of diabetic nephropathy Kidney glomeruli from 3 diabe...
ORGANISM(S): Mus musculus 
2016-10-24 | E-GEOD-77717 | biostudies-arrayexpress
TranscriptomicsKKTa_isolated glomeruli
High dietary fat intake is a major risk factor for the development of obesity, which is frequently associated with diabetes. To identify genes involved in diabetic nephropathy, GeneChip Expression Analysis was employed to survey the glomerular gene expression profile in diabetic KK/Ta mice fed with ...
ORGANISM(S): Mus musculus 
2010-12-01 | E-GEOD-19251 | biostudies-arrayexpress
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