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TranscriptomicsVitamin D3 affects TNFa mediated activation of dendritic cells
The ability of dendritic cells (DC) to initiate immunity and induce antigen-specific tolerance makes DC ideal targets for pharmacological intervention into immune responses. NF-kB factors are a family of transcriptional regulators important for DC development and function. However, the identity of N...
ORGANISM(S): Mus musculus 
2012-12-31 | E-GEOD-8334 | biostudies-arrayexpress
TranscriptomicsMolecular architecture of transcription factor hotspots in early adipogenesis
Here, we have used digital genomic footprinting to precisely define protein localization for several adipogenic transcription factors at a genome-wide level. In combination with ChIP-seq data, these analyses reveal novel molecular insight into the organization of transcription factors at hotpot regi...
ORGANISM(S): Mus musculus 
2014-05-08 | E-GEOD-57415 | biostudies-arrayexpress
UnknownResponse to physical rehabilitation and recovery trajectories following critical illness: individual participant data meta-analysis protocol.
Not available
S-EPMC7223158 | biostudies-literature
TranscriptomicsBlood mRNA expression signatures derived from unsupervised analyses identify prostate cancers with poor outcome
Background: Inter-patient prostate cancer (PrCa) heterogeneity results in highly variable patient outcomes. Multi-purpose biomarkers to dissect this heterogeneity are urgently required to improve treatment and accelerate drug development in PrCa. Circulating biomarkers are most practical for evaluat...
ORGANISM(S): Homo sapiens 
2012-10-15 | E-GEOD-37199 | biostudies-arrayexpress
ProteomicsComplete integration of carbene-transfer chemistry into biosynthesis
Biosynthesis is an environmentally friendly and renewable way to synthesize a broad range of natural and some new-to-nature products; however, it lacks many of the reactions and flexibility of synthetic chemistry, an example being carbene mediated reactions. While it was recently shown that these re...
ORGANISM(S): Streptomyces albus J1074 
2023-05-03 | PXD037509 | Pride
Streptomyces albus P450 Biosynthesis Carbene meidated reaction 
ProteomicsMass-spectrometry phosphoproteomics of Calu-3 cell lines infected with SARS-CoV-2, in comparison to non-infected and UV mock-treated cell lines
To identify the proteome alterations in human epithelial cells upon SARS-CoV-2 infection, we performed an in vitro experiment, where we infected lung-adenocarcinoma cultured human airway epithelial cells (Calu-3) with an isolate of the ancestral variant and alpha variant of SARS-CoV-2 in two separat...
ORGANISM(S): Homo sapiens (Human) 
2023-09-01 | PXD040982 | Pride
Covid-19 Phosphosites Ph fractionation Human Sars-cov-2 Calu-3 cell line Infection Phosphoproteomics Lc-ms/ms 
ProteomicsTargeting cholesterol homeostasis eliminates drug-tolerant persister cells in glioblastoma
The transition of cancer cells between drug-sensitive and drug-tolerant persister phenotypes drives treatment failures. Using glioblastoma models, we identified MRK-740, an inhibitor of H3K4 methyltransferase PRDM7/9, as a potent enhancer of chemotherapy-induced cell death, resulting in elimination ...
ORGANISM(S): Homo sapiens (Human) 
2025-12-22 | PXD050643 | Pride
Gliobastomas Histones Microtubule-targeting agents 
UnknownA comprehensive iterative approach is highly effective in diagnosing individuals who are exome negative.
Not available
S-EPMC6295275 | biostudies-literature
UnknownHaptoglobin phenotype and abnormal uterine artery Doppler in a racially diverse cohort.
Not available
S-EPMC4096612 | biostudies-literature
UnknownFostamatinib for Hospitalized Adults With COVID-19 and Hypoxemia: A Randomized Clinical Trial.
Not available
S-EPMC11615712 | biostudies-literature
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