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ProteomicsNative Mass Spectrometry of Soluble Proteins with Sodium Chloride enabled by a Dendritic Detergent
Salts are pivotal for ligand binding but hamper the analysis of proteins through native mass spectrometry due to adduct formation and consequent signal suppression. Here, we show how to facilitate native mass spectrometry of soluble proteins and protein–ligand complexes in the presence of sodium chl...
ORGANISM(S): Bos taurus (Bovine) Oryctolagus cuniculus (Rabbit) Pseudomonas aeruginosa PAO1 Saccharomyces cerevisiae (Baker's yeast) Equus caballus (Horse) 
2026-09-14 | PXD074233 | Pride
ProteomicsStructural snapshots of Pseudomonas aeruginosa LptB2FG and LptB2FGC reveal insights into lipopolysaccharide recognition and transport - native mass spectrometry data
Gram-negative bacteria are intrinsically resistant to many antibiotics because of densely packed lipopolysaccharides (LPS) in the outer leaflet of their outer membrane (OM), which acts as a highly effective barrier towards the spontaneous permeation of toxic molecules, including antibiotics. LPS are...
ORGANISM(S): Pseudomonas aeruginosa PAO1 
2025-10-22 | PXD069660 | Pride
Lipopolysaccharide Lps Native ms Lptb2fg P. aeruginosa Lptb2fgc 
ProteomicsDynamics of an LPS translocon induced by substrate and an antimicrobial peptide
We investigated the conformational dynamics of the LPS translocon LptDE was using hydrogen-deuterium exchange mass spectrometry. We evaluated the conformational changes of LptDE upon binding of LPS, Re-LPS (an LPS substructure), thanatin, and the membrane lipid POPG. Our data reveal that LPS induces...
ORGANISM(S): Klebsiella pneumoniae 
2020-11-16 | PXD021743 | Pride
Lps Hydrogen-deuterium exchange Hdx-ms Thanatin Lptde 
ProteomicsStructural characterisation of the fungal Pmt4 homodimer - native MS and lipidomics
Protein O-mannosyltransferases (PMTs) are conserved endoplasmic reticulum membrane embedded enzymes responsible for the transfer of mannose from dolichol phosphate-mannose (Dol-P-Man) to serine/threonine-rich protein substrates or unfolded proteins. PMTs from three subfamilies form obligate dimers w...
ORGANISM(S): Saccharomyces cerevisiae Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) 
2025-11-19 | PXD061837 | Pride
UnknownSearching for a second excitation in the inelastic neutron scattering spectrum of a liquid metal: a Bayesian analysis.
Not available
S-EPMC8263748 | biostudies-literature
MetabolomicsMetabolomic/lipidomic profiling of COVID-19 and individual response to tocilizumab
The current pandemic emergence of novel coronavirus disease (COVID-19) poses a relevant threat to global health. SARS-CoV-2 infection is characterized by a wide range of clinical manifestations, ranging from absence of symptoms to severe forms that need intensive care treatment. Here, plasma-EDTA sa...
2022-02-21 | MTBLS2336 | MetaboLights
UnknownRoom temperature amine sensors enabled by sidewall functionalization of single-walled carbon nanotubes.
Not available
S-EPMC6390973 | biostudies-literature
UnknownVEGF-121 plasma level as biomarker for response to anti-angiogenetic therapy in recurrent glioblastoma.
Not available
S-EPMC5946426 | biostudies-literature
UnknownThe Effect of Embedded Nanoparticles on the Phonon Spectrum of Ice: An Inelastic X-ray Scattering Study.
Not available
S-EPMC10005414 | biostudies-literature
UnknownAssessment of seasonal variation of diet composition in rodents using DNA barcoding and Real-Time PCR.
Not available
S-EPMC6773709 | biostudies-literature
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