Sort   by:  
 Page size 
ProteomicsIntegrated omic analysis reveals multilevel control of renal and systemic metabolism by the renal tubular circadian clock
Circadian rhythmicity in renal function suggests a requirement for circadian adaptations in renal metabolism. We studied circadian changes in renal metabolic pathways using integrated transcriptomic, proteomic and metabolomic analysis performed on control mice and mice deficient in the circadian clo...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-15 | PXD036803 | Pride
Mouse kidney  control mice  mice ko for arntl in the renal tubule  renal circadian proteome 
TranscriptomicsTranscription profiling of mouse nephron to assess circadian rhythms
Renal excretion of water and major electrolytes exhibits a significant circadian rhythm. This functional periodicity is believed to result, at least in part, from circadian changes in secretion/reabsorption capacities of the distal nephron and collecting ducts. Here, we studied the molecular mechani...
ORGANISM(S): Mus musculus 
2009-10-30 | E-GEOD-17739 | biostudies-arrayexpress
TranscriptomicsTranscriptome of a mouse kidney cortical collecting duct cell line: effects of aldosterone and vasopressin
In this study, we analyzed the transcriptome of a highly differentiated mouse clonal CCD principal cell line (mpkCCD(cl4)) and the changes in the transcriptome induced by aldosterone and vasopressin. Serial analysis of gene expression (SAGE) was performed on untreated cells and on cells treated with...
ORGANISM(S): Mus musculus 
2003-09-24 | E-GEOD-678 | biostudies-arrayexpress
TranscriptomicsTargeted deletion of circadian clock gene Arntl in the nephron results in dysregulation of diverse metabolic pathways
The circadian clock controls a wide variety of metabolic and homeostatic processes in a number of tissues, including the kidney. However, the role of the renal circadian clocks remains largely unknown. To address this question we performed transcriptomic analysis in mice with inducible and condition...
ORGANISM(S): Mus musculus 
2016-06-01 | E-GEOD-76838 | biostudies-arrayexpress
TranscriptomicsMice lacking circadian transcriptional activator Clock exhibit dramatic changes in renal excretory rhythms
Recent evidence suggest that the circadian timing system plays an important role in the control of renal function and maintaining blood pressure. Here, we analyzed circadian rhythms of urinary excretion of sodium and potassium in wild-type mice and mice lacking circadian transcriptional activator cl...
ORGANISM(S): Mus musculus 
2012-04-29 | E-GEOD-27366 | biostudies-arrayexpress
Sort   by:  
 Page size