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ProteomicsDisulfide mapping of J-chain by crosslinking MS
Here we show how J-chain (JC) outcompetes the sixth IgM subunit during assembly. We looked at the disulfide re-arrangements in JC and showed that it exists as an unstructured protein with non-native disulfides before its insertion into IgM.
ORGANISM(S): Mus musculus (Mouse) 
2024-12-04 | PXD048614 | Pride
Disulfide J-chain Crosslinking 
MetabolomicsContributions of the Microbiome-Derived Metabolome for Risk Assessment and Prognostication of Pancreatic Cancer

BACKGROUND Increasing evidence implicates microbiome involvement in the development and progression of pancreatic ductal adenocarcinoma (PDAC). Studies suggest that reflux of gut or oral microbiota can lead to colonization in the pancreas, resulting in dysbiosis that culminates ...

2023-08-09 | MTBLS7260 | MetaboLights
UnknownRadical cystectomy in patients aged < 80 years versus ≥ 80 years: analysis of preoperative geriatric assessment scores in predicting postoperative morbidity and mortality.
Not available
S-EPMC11442567 | biostudies-literature
ProteomicsHAP40 orchestrates huntingtin structure for differential interaction with polyglutamine expanded exon 1
Huntington’s disease results from expansion of a glutamine-coding CAG tract in the huntingtin (HTT) gene, producing an aberrantly functioning form of HTT. Both wildtype and disease-state HTT form a hetero-dimer with HAP40 of unknown functional relevance. We demonstrate in vivo and in cell models tha...
ORGANISM(S): Homo sapiens (Human) 
2022-09-09 | PXD028415 | Pride
Saxs Huntingtin Xl-ms Cryo-em Integrative modeling 
ProteomicsHAP40 orchestrates huntingtin structure for differential interaction with polyglutamine expanded exon 1
Huntington’s disease results from expansion of a glutamine-coding CAG tract in the huntingtin (HTT) gene, producing an aberrantly functioning form of HTT. Both wildtype and disease-state HTT form a hetero-dimer with HAP40 of unknown functional relevance. We demonstrate in vivo and in cell models tha...
ORGANISM(S): Homo sapiens (Human) 
2022-02-21 | PXD028313 | Pride
Saxs Huntingtin Xl-ms Cryo-em Integrative modeling 
UnknownExtracting the Auditory Attention in a Dual-Speaker Scenario From EEG Using a Joint CNN-LSTM Model.
Not available
S-EPMC8365753 | biostudies-literature
UnknownDifferentiation of Polyamide 6, 6.6, and 12 Contaminations in Polyolefin-Recyclates Using HPLC Coupled to Drift-Tube Ion-Mobility Quadrupole Time-of-Flight Mass Spectrometry.
Not available
S-EPMC8235147 | biostudies-literature
UnknownAn ancestral allele of grapevine transcription factor MYB14 promotes plant defence.
Not available
S-EPMC4783363 | biostudies-literature
UnknownMaternal eNOS deficiency determines a fatty liver phenotype of the offspring in a sex dependent manner.
Not available
S-EPMC4939931 | biostudies-literature
UnknownDevelopment of an LC-MS method for the semiquantitative determination of polyamide 6 contaminations in polyolefin recyclates.
Not available
S-EPMC7813719 | biostudies-literature
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