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MetabolomicsExtreme genome diversity and cryptic speciation in a harmful algal bloom forming eukaryote

Harmful algal blooms (HABs) of the toxic haptophyte Prymnesium parvum are a recurrent problem in many inland and estuarine waters around the world. Strains of P. parvum vary in the toxins they produce and in other physiological traits associated with HABs, but the genetic basis ...

2023-04-26 | MTBLS5893 | MetaboLights
TranscriptomicsTranscription profiling of rat model of aging - progressive aortic vasculopathy
This study utilized a standard rat model of aging and global gene expression analyses to attempt to identify the most appropriate time points to study vascular aging and to identify molecules associated with the development of pathology. Recent studies have established that age is the major risk fac...
ORGANISM(S): Rattus norvegicus 
2008-06-15 | E-GEOD-7281 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of F344/N rats administered with potassium bromate in the drinking water
Ozone has been proposed for water disinfection because it is more efficient than chlorine for killing microbes and results in much lower levels of carcinogenic trihalomethanes than does chlorination. Ozone leads to formation of hypobromous acid in surface waters with high bromine content and forms b...
ORGANISM(S): Rattus norvegicus 
2006-11-14 | E-TOXM-21 | biostudies-arrayexpress
TranscriptomicsSmall RNA sequencing in mouse cardiomyocytes after siRNA mediated knockdown of Srf
We performed two independent siRNA mediated knockdowns of Srf (Srf si1 & Srf si2) and an unspecific siRNA (siNon) in mouse cardiomyocytes HL-1 cells. Small RNAs were sequenced by Illumina/Solexa next-generation (single-end) sequencing technology. The sequence reads were mapped to the mouse reference...
ORGANISM(S): Mus musculus 
2011-01-03 | E-GEOD-19066 | biostudies-arrayexpress
TranscriptomicsInduction of the neuronal major histocompatibility complex class I and paired immunoglobulin-like receptor B pathway in the hippocampus with aging and cognitive decline
The aim of this study was to identify alterations in hippocampal synaptic mRNA expression with aging and cognitive decline. Transcriptional profiling and subsequent bioinformatic analysis was performed to identify the most highly regulated pathways of genes. Interestingly, the antigen processing a...
ORGANISM(S): Rattus norvegicus 
2011-10-29 | E-GEOD-29511 | biostudies-arrayexpress
UnknownInherited mutations in 17 breast cancer susceptibility genes among a large triple-negative breast cancer cohort unselected for family history of breast cancer.
Not available
S-EPMC4302212 | biostudies-literature
UnknownCardiometabolic outcomes with dapagliflozin after myocardial infarction by baseline ejection fraction: DAPA-MI.
Not available
S-EPMC12719873 | biostudies-literature
ProteomicsEicosadomics, proteomics and metabolomics of inflammatory stimulated human fibroblasts reveals specific functions related to chronic inflammation - secreted proteins of inflammatory stimulated cells
Fibroblasts have only recently been identified as important effector cells in inflammation. In this study, human dermal fibroblasts were inflammatory stimulated with interleukin-1beta and comprehensively analysed with respect to proteins, eicosanoids and metabolites. For eicosadomics, we have establ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-04-02 | MSV000080879 | MassIVE
ProteomicsEicosadomics, proteomics and metabolomics of inflammatory stimulated human fibroblasts reveals specific functions related to chronic inflammation - cytoplasmic proteins of dexamethasone-treated inflammatory stimulated cells
Fibroblasts have only recently been identified as important effector cells in inflammation. In this study, human dermal fibroblasts were inflammatory stimulated with interleukin-1beta and comprehensively analysed with respect to proteins, eicosanoids and metabolites. For eicosadomics, we have establ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-16 | MSV000080644 | MassIVE
TranscriptomicsMolecular characterization of 4-NQO induced F344 rat tongue carcinogenesis: alteration of multiple gene expression and hypomethylation of PTGS2 proximal promoter
The 4-NQO induced rat tongue carcinogenesis model presenting considerable histologic and molecular similarity to oral cancers commonly seen in humans is very useful for investigating oral carcinogenesis. In order to understand the molecular basis of oral carcinogenesis and identify gene biomarkers ...
ORGANISM(S): Rattus norvegicus 
2014-08-04 | E-GEOD-51125 | biostudies-arrayexpress
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