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ProteomicsDesign of a potent, selective and brain penetrant inhibitor of Wnt-deactivating enzyme Notum by optimization of a crystallographic fragment hit
Notum is a carboxylesterase that suppresses Wnt signaling through deacylation of an essential palmitoleate group on Wnt proteins. There is a growing understanding of the role Notum plays in human disease such as colorectal cancer and Alzheimer’s disease supporting the need to discover improved inhib...
ORGANISM(S): Homo sapiens (Human) Rattus norvegicus (Rat) 
2022-06-09 | PXD031338 | Pride
Lc-msms Carboyxlesterase Notum Inhibitor Wnt signalling 
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Not available
S-EPMC4162127 | biostudies-literature
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S-EPMC8652887 | biostudies-literature
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