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GenomicsNOTUM-MEDIATED WNT SILENCING DRIVES EXTRAVILLOUS TROPHOBLAST CELL LINEAGE DEVELOPMENT [Notum knockdown]
NOTUM-MEDIATED WNT SILENCING DRIVES EXTRAVILLOUS TROPHOBLAST CELL LINEAGE DEVELOPMENT [Notum knockdown]
PRJNA848824 | ENA
TranscriptomicsGene expression analysis of HepG2 cells by NOTUM RNAi
We identified human NOTUM, a new member of beta-catenin target gene. The aim of this analysis is to examine downstream genes of NOTUM. Keywords: Gene expression analysis in response to RNA interference HepG2 cells with RNAi duplexed were used. One control (control-low GC) and 2 RNAi duplexes (NOTUM ...
ORGANISM(S): Homo sapiens 
2011-03-15 | E-GEOD-6368 | biostudies-arrayexpress
ProteomicsDesign of a potent, selective and brain penetrant inhibitor of Wnt-deactivating enzyme Notum by optimization of a crystallographic fragment hit
Notum is a carboxylesterase that suppresses Wnt signaling through deacylation of an essential palmitoleate group on Wnt proteins. There is a growing understanding of the role Notum plays in human disease such as colorectal cancer and Alzheimer’s disease supporting the need to discover improved inhib...
ORGANISM(S): Homo sapiens (Human) Rattus norvegicus (Rat) 
2022-06-09 | PXD031338 | Pride
Lc-msms Carboyxlesterase Notum Inhibitor Wnt signalling 
GenomicsNotum Regulates the Cusp and Root Patterns in Mouse Molar
Notum Regulates the Cusp and Root Patterns in Mouse Molar
PRJNA1077289 | ENA
TranscriptomicsTranscriptome perturbation analysis from 16 hours APF Drosophila notum.
Genome-wide transcriptome analysis of genetic pertubations induced in Drosophila notum by the over-expression of the transcription factors Achaete, Asense, E(spl)m3-HLH and Senseless. Transient over-expression of GFP (control), Achaete (Ac), Senseless (Sens), Asense (Ase) and E(spl)m3-HLH transcript...
ORGANISM(S): Drosophila melanogaster 
2014-01-01 | E-GEOD-53010 | biostudies-arrayexpress
UnknownNotum deacylates octanoylated ghrelin.
Not available
S-EPMC8010218 | biostudies-literature
TranscriptomicsNOTUM-MEDIATED WNT SILENCING DRIVES EXTRAVILLOUS TROPHOBLAST CELL LINEAGE DEVELOPMENT [Notum knockdown]
WNT activated signal transduction is a conserved regulator of morphogenesis of many organ systems, including the placenta. In human trophoblast stem (TS) cells, activation of canonical WNT signaling is a key to maintenance of the TS cell stem state. NOTUM, a negative regulator of canonical WNT signa...
ORGANISM(S): Homo sapiens 
2024-03-06 | GSE206035 | GEO
TranscriptomicsNotum Regulates the Cusp and Root Patterns in Mouse Molar
Notumis a direct target of Wnt/β-catenin signaling and plays a crucial role as a Wnt inhibitor within a negative feedback loop. In the tooth, Notum is known to be expressed in odontoblasts, and severe dentin defects and irregular tooth roots have been reported in Notum-deficient mice. However, the p...
ORGANISM(S): Mus musculus 
2024-06-10 | GSE255946 | GEO
GenomicsNOTUM-MEDIATED WNT SILENCING DRIVES EXTRAVILLOUS TROPHOBLAST CELL LINEAGE DEVELOPMENT [CHIR99021]
NOTUM-MEDIATED WNT SILENCING DRIVES EXTRAVILLOUS TROPHOBLAST CELL LINEAGE DEVELOPMENT [CHIR99021]
PRJNA848827 | ENA
TranscriptomicsGene expression analysis of HepG2 cells by NOTUM RNAi
We identified human NOTUM, a new member of beta-catenin target gene. The aim of this analysis is to examine downstream genes of NOTUM. Keywords: Gene expression analysis in response to RNA interference
ORGANISM(S): Homo sapiens 
2011-03-15 | GSE6368 | GEO
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