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TranscriptomicsCaloric restriction induces heat shock response and inhibits B16F10 cell tumorigenesis both in vitro and in vivo
Caloric restriction (CR) without malnutrition is one of the most consistent strategies for increasing mean and maximal lifespan and delaying the onset of age-associated diseases. Stress resistance is a common trait of many long-lived mutants and life-extending interventions, including CR. Indeed, be...
ORGANISM(S): Mus musculus 
2015-08-06 | E-GEOD-67430 | biostudies-arrayexpress
TranscriptomicsComparison of the long-term effects of calorie restriction without malnutrition on global gene expression profiles of rat and human skeletal muscle [Rat]
With the population of older and overweight individuals on the rise in the Western world, there is an ever greater need to slow the aging processes and reduce the burden of age-associated chronic disease that would significantly improve the quality of human life and reduce economic costs. Caloric re...
ORGANISM(S): Rattus norvegicus 
2013-08-01 | E-GEOD-38062 | biostudies-arrayexpress
TranscriptomicsscRNA-seq of human fetal lung explants with R-SPONDIN Inhibition and human fetal lung primary tissue
Here, we used single cell RNA-sequencing (scRNA-seq) to profile 13-week post-conception distal human fetal lung explants cultured in an air liquid interface system and treated with an LGR5 ectodomain adenovirus that inhibits R-Spondin function or control adenovirus. A third, non-infected, condition ...
ORGANISM(S): Homo sapiens 
2022-01-01 | E-MTAB-10662 | biostudies-arrayexpress
ProteomicsDevelopment of a New N-Terminomic Method to Study the Pathodegradome of the Staphylococcus aureus V8 Protease in Human Neutrophils
Staphylococcus aureus is a notorious human pathogen that relies on an array of virulence factors to engender infection and evade the host-immune system. Among these are the secreted proteases, which promote pathogenesis by degrading host proteins and modulating host-defenses. Human neutrophils play ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-30 | PXD057551 | Pride
Degradomics Neutrophils Tags-cr Immune dysregulation. Staphylococcus aureus V8 protease 
ProteomicsThe accessory type III secretion system effectors shape inflammatory infection outcome
Injection of effectors via a type III secretion system (T3SS) is an infection strategy shared by many Gram-negative bacterial pathogens. While individual T3SS effectors are well characterized, their network-level organization and the distinction between core and accessory effectors remain incomplete...
ORGANISM(S): Homo sapiens (Human) 
2025-04-16 | PXD062886 | Pride
Type iii secretion system 
MetabolomicsDiagnostic Potential of Plasma IgG N-glycans in Discriminating Thyroid Cancer from Benign Thyroid Nodules and Healthy Controls

BACKGROUND: Novel biomarkers are urgently needed to distinguish between benign and malignant thyroid nodules and detect thyroid cancer in the early stage. The associations between serum IgG N-glycosylation and thyroid cancer risk have been revealed. We aimed to explore the potent...

2021-09-01 | MTBLS2935 | MetaboLights
TranscriptomicsIntestinal Salmonella Typhimurium infection leads to miR-29a induced Caveolin 2 regulation [miRNA]
The host response to S.typhimurium infections in ileum was studied after infection of piglets. mRNA and miRNA expression studies were performed to identify interactions of miRNAs and regulated mRNAs in context of mammalian intestinal Salmonella infection using a piglet model. Intestinal samples (~ 2...
ORGANISM(S): Sus scrofa 
2013-06-25 | E-GEOD-40803 | biostudies-arrayexpress
ProteomicsOrgan protection by caloric restriction depends on activation of the de novo NAD+ synthesis pathway
Therapeutic strategies to treat acute kidney injury (AKI) are lacking. Preconditioning by hypoxia (HP) and caloric restriction (CR) is highly protective in rodent AKI models. The underlying molecular mechanisms are unknown. A comparative transcriptome analysis after HP and CR identified Kynureninase...
ORGANISM(S): Mus musculus (Mouse) 
2023-02-13 | PXD038328 | Pride
Kynu Hypoxia Caloric restriction Acute kidney injury Kynureninase Nad+ 
ProteomicsHuman alveolar bone and dental cementum LC-MSMS
First report of proteomic composition of human matched-samples (n=7) of alveolar bone (AB) and dental cementum (DC). Bone samples were harvested from tooth extraction sites, whereas DC samples were obtained from the apical root portion of extracted third molars. Samples were denatured, followed by ...
ORGANISM(S): Homo sapiens (Human) 
2013-09-09 | PXD000420 | Pride
Human Lc-msms Alveolar bone Dental cementum 
ProteomicsUstilago maydis disrupts carbohydrate signaling networks to induce hypertrophy in maize mesophyll cells (total and phospho proteome data)
Ustilago maydis is a biotrophic fungus that infects arial parts of maize, secreting effector proteins to facilitate host colonization and manipulate cellular processes, creating nutrient-rich environments for its growth and reproduction. Here, we identified three effectors (Hap1-3; hypertrophy-assoc...
ORGANISM(S): Zea mays (Maize) 
2026-01-28 | PXD057676 | Pride
Ustilago maydis Zea mays Hypertrophy Snrk1 Plant immunity 
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