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TranscriptomicsMicroarrays of SK-N-AS cells at 37 and 40 degrees C treated with TNFalpha
In this data set we investigate dynamic differences in the transcriptome between 37 and 40 degrees C after treatment with TNFalpha. In the continuous temperature experiments, cells were grown at 37 degrees C and were then left at 37 degrees C, or transferred to 40 degrees C, for 1hour after which t...
ORGANISM(S): Homo sapiens 
2018-04-05 | E-MTAB-5158 | biostudies-arrayexpress
TranscriptomicsLMWF_EC
ECFCs and HUVECs were washed and placed overnight in EBM-2 + 2% FCS. The next morning, medium was replaced by EBM-2 + 2% FCS + 10 µg/mL LMWF or by EBM-2 + 2% FCS alone. After 6 hours or 24 hours of treatment, cells were washed with PBS, detached with accutase. After washing and centrifugation steps,...
ORGANISM(S): Homo Sapiens 
2016-09-25 | E-MTAB-3925 | biostudies-arrayexpress
TranscriptomicsRNAseq of tumor samples from CT26 syngeneic mouse treated with a PI3Ka/d inhibitor (AZD8835)
PI3K inhibitors with differential selectivity to distinct PI3K isoforms have been tested extensively in clinical trials, largely to target tumor epithelial cells. PI3K signaling also regulates the immune system and inhibition of PI3Kdelta modulate the tumor immune microenvironment of pre-clinical mo...
ORGANISM(S): Mus musculus 
2019-01-08 | E-MTAB-7386 | biostudies-arrayexpress
MetabolomicsStrong effect of Penicillium roqueforti populations on volatile and metabolic compounds responsible for aromas, flavour and texture in blue cheeses
Studies of food microorganism domestication can provide important insight into adaptation mechanisms and lead to commercial applications. Penicillium roqueforti is a fungus with four genetically differentiated populations, two of which were independently domesticated for blue cheese-making, with the...
2021-10-06 | MTBLS1509 | MetaboLights
TranscriptomicsTranscription profiling of expressed human chromosome 21 genes in transchromosomic mouse embryos carrying a freely segregating copy of Hsa21
Detection of expressed human chromosome 21 genes in transchromosomic mouse embryos carrying a freely segregating copy of Hsa21.
ORGANISM(S): Mus musculus 
2005-11-19 | E-MEXP-409 | biostudies-arrayexpress
TranscriptomicsStranded Total RNA-seq of liver biopsy collected from Holstein Friesian cows that were defined from cluster analysis as being metabolically "balanced", "imbalanced" or "other
Homeorhetic mechanisms assist dairy cows to transition from pregnancy to lactation. In some cows this is less successful and they develop severe negative energy balance, placing them at risk of metabolic and infectious disease and reduced fertility. We placed Holstein Friesian cows into metabolicall...
ORGANISM(S): Bos taurus 
2021-07-09 | E-MTAB-9348 | biostudies-arrayexpress
TranscriptomicsGene expression analysis of cultured rat primary proximal tubular cells (PTC) after isolation and differentiation
The aim of this study is to evaluate the transcripitomics changes during dedifferentiation up to 7 days in a transwell system of rat primary proximal tubular cell (PTC) cultures isolated from rat kidneys. Samples were taken from freshly isolated PTC (0 days) and at timeponts during PTC differentiati...
ORGANISM(S): Rattus norvegicus 
2024-06-30 | E-MTAB-13633 | biostudies-arrayexpress
MetabolomicsContribution of fungal microbiome to intestinal physiology, early-life immune development and mucosal inflammation in mice
The gut microbiome consists of a multi-kingdom microbial community. Whilst the role of bacteria as causal contributors governing host physiological development is well established, the role of fungi remains to be determined. Here, we use germ-free mice colonized with defined species of bacteria, fun...
2022-01-14 | MTBLS1679 | MetaboLights
TranscriptomicsRNAseq of small intestinal organoids from mice treated with the cytokines IL-13 and IL-22 for 72 hours in combination with the BMP signaling inhibitor DMH1
The intestinal epithelium is our first line of defense against infections of the gut and the plasticity in cellular differentiation of the intestinal epithelium is an important part of this response. The changes in cellular composition is driven by immune cell derived cytokines. Here we use signatur...
ORGANISM(S): Mus musculus 
2022-05-08 | E-MTAB-9185 | biostudies-arrayexpress
TranscriptomicsWhole blood RNA-sequencing from volunteers in a human influenza challenge study, in which blood aliquots were infected and incubated with BCG before and after influenza infection
We aimed to test the hypothesis that influenza infection of healthy adults alters whole blood mycobacterial control through modulation of anti-mycobacterial immune responses. We employed a whole blood mycobacterial growth inhibition assay within the framework of a human influenza challenge study. W...
ORGANISM(S): Homo sapiens 
2026-06-11 | E-MTAB-15137 | biostudies-arrayexpress
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