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MetabolomicsGlobal metabolomics of fireflies (Coleoptera: Lampyridae) explore metabolic adaptation to fresh water in insects

Aquatic insects are well-adapted to freshwater environments, but metabolic mechanisms of such adaptations, particularly to primary environmental factors (e.g., hypoxia, water pressure, dark light and abundant microbes), are poorly known. Most firefly species (Coleoptera: Lampyridae) are terrestri...

2022-10-03 | MTBLS4987 | MetaboLights
MetabolomicsTFAM loss induces nuclear actin assembly upon mDia2 malonylation to promote liver cancer metastasis
The mechanisms underlying cancer metastasis remain poorly understood. Here, we report that TFAM deficiency rapidly and stably induced spontaneous lung metastasis in mice with liver cancer. Interestingly, unexpected polymerization of nuclear actin was observed in TFAM-knockdown HCC cells when cytoske...
2022-06-23 | MTBLS4307 | MetaboLights
UnknownAn emerging terpolymeric nanoparticle pore former as an internal recrystallization inhibitor of celecoxib in controlled release amorphous solid dispersion beads: Experimental studies and molecular dynamics analysis.
Not available
S-EPMC11143779 | biostudies-literature
TranscriptomicsCalcitriol deregulates AR signaling to inhibit prostate cancer progression in the TRAMP model
The mechanism of action of vitamin D in prostate cancer (PCa) remains poorly defined, with most mechanisms identified being highly cell type and model specific. One of the underlying factors for these diverse mechanisms may be the use of overly simplistic in vitro model systems to study the complex ...
ORGANISM(S): Mus musculus 
2015-03-02 | E-GEOD-57382 | biostudies-arrayexpress
ProteomicsTargeted Depletion of Monocyte/Macrophage Suppresses Aortic Dissection with the Spatial Regulation of MMP-9 in the Aorta
The peptide samples were analyzed by LC-MS/MS with a Q-Exactive mass spectrometer (Thermo Fisher, MA, USA) equipped with EASY-nLC 1200 liquid chromatography. The spectrometer was controlled by Xcalibur software, version 4.0 (Thermo Fisher, MA, USA). The peptides were separated on a C18 capillary col...
ORGANISM(S): Mus Musculus 
2020-11-18 | PXD022592 |
TranscriptomicsTranscription profiling of wild type and mutants of Sultan V barley plants
A large-scale time course expression profiling of wild type (Mla12/Rar1/Rom1) and mutants (mla12-M66, M82 (rar1-1), M100 (rar1-2) and rom1) of barley cultivar Sultan 5 was conducted to understand the molecular mechanisms of delayed powdery mildew resistance. Barley plants were inoculated with powder...
ORGANISM(S): Hordeum vulgare 
2006-08-11 | E-TABM-82 | biostudies-arrayexpress
MetabolomicsPlasma Lipidomics Identifies Anticedent Memory Impairment in Older Adults
Alzheimer's disease causes a progressive dementia that currently affects over 35 million individuals worldwide and is expected to affect 115 million by 2050 (ref. 1). There are no cures or disease-modifying therapies, and this may be due to our inability to detect the disease before it has progresse...
2014-03-09 | MTBLS72 | MetaboLights
TranscriptomicsPoly(A)-Specifc Ribonuclease 1 (PARN-1) Overexpression in Procyclic T. brucei
We sought to determine the effect of TbPARN-1 overexpression on global mRNA steady-state levels in T. brucei. The mRNA expression profile of tet-induced TbPARN-1 OvEx procyclic cells was compared to the mRNA profile of control cells (expressing tet-induced TAP tag alone) by microarray analysis. S...
ORGANISM(S): Trypanosoma brucei 
2010-03-04 | E-GEOD-20593 | biostudies-arrayexpress
TranscriptomicsWhole genome scanning of lung tumors and mucosal biopsies on Affymetrix NspI-250K platform
Matched normal lymph node, tumors and corresponding mucosal biopsies from 4 lung cancer patients were scrutinized on Affymetrix 250K-NspI array platform. Frequently deleted regions genes were identified based on the LOH call as per manufacturer's guidelines and normalization. Frequently deleted gene...
ORGANISM(S): Homo sapiens 
2013-01-11 | E-GEOD-29365 | biostudies-arrayexpress
UnknownLandscape of genomic diversity and trait discovery in soybean.
Not available
S-EPMC4814817 | biostudies-literature
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