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MetabolomicsFecal microbiota transplantation plus anti-PD-1 immunotherapy in advanced melanoma: a phase I trial

Fecal microbiota transplantation (FMT) represents a potential strategy to overcome resistance to immune checkpoint inhibitors in patients with refractory melanoma; however, the role of FMT in first-line treatment settings has not been evaluated. We conducted a multicenter phase I trial combining ...

2025-02-27 | MTBLS711 | MetaboLights
ProteomicsDiscovery of a Small Molecule Secreted Clustering Enhancer that Improves Memory in Alzheimer's Disease Mice
Here, we present findings from a drug discovery program aimed at developing small molecules that enhance brain sCLU levels and assessed their impact on AD pathology and cognition. A high-throughput screening campaign identified two classes of epigenetic modulators to increase sCLU levels, and medici...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-30 | PXD060171 | Pride
Alzheimers disease Epigenetic modulator Memory improvement Secreted clustering enhancer 
ProteomicsDiscovery of a Small Molecule Secreted Clustering Enhancer that Improves Moemory in Alzheimer's Disease Mice
Here, we present findings from our drug discovery program to identify small molecules that enhance sCLU levels and assess their impact on AD pathology and cognition in a murine model of AD. A high-throughput screening campaign identified two classes of epigenetic modulators that increase sCLU levels...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-30 | PXD060173 | Pride
Epigenetic modulator Alzheimer's disease Memory improvement Secreted clustering enhancer 
MetabolomicsMetabolic phenotyping of urine from a dementia research cohort
To better understand the molecular mechanisms underpinning physiological variation in human populations, metabolic phenotyping approaches are increasingly being applied to studies involving hundreds and thousands of biofluid samples. Hyphenated ultra-performance liquid chromatography-mass spectromet...
2022-03-01 | MTBLS719 | MetaboLights
ProteomicsUnbiased proteomic profiling uncovers a targetable GNAS/PKA/PP2A axis in SCLC
Using unbiased kinase profiling, we identified protein kinase A (PKA) as an active kinase in small cell lung cancer (SCLC). Inhibition of PKA activity genetically, or pharmacologically by activation of the PP2A phosphatase, inhibits SCLC expansion in culture and in vivo. Conversely, GNAS (G-protein ...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2020-06-17 | PXD018209 | Pride
Inhibitor beads Analog specific Kinase proteomics Small cell lung cancer 
UnknownHigh frequency of gastrointestinal manifestations in myotonic dystrophy type 1 and type 2.
Not available
S-EPMC5649763 | biostudies-literature
ProteomicsMolecular basis for differential activation of p101 and p84 complexes of PI3Kg by Ras and GPCRs
Using hydrogen deuterium exchange mass spectrometry, we reveal molecular differences between the two p110g-p84 and p110g-p101 complexes that explain their differential activation.
ORGANISM(S): Homo sapiens (Human) 
2023-03-09 | PXD035723 | Pride
Pi3kg P101 Ras P110g Hdx-ms Hdx Gby 
UnknownThe impact of viral mutations on recognition by SARS-CoV-2 specific T cells.
Not available
S-EPMC8552693 | biostudies-literature
TranscriptomicsWhole blood gene expression profiles distinguish clinical phenotypes of venous thromboembolism [Set1]
Recurrent venous thromboembolism (VTE) occurs infrequently following a provoked event but occurs in up to 30% of individuals following an initial unprovoked event. We studied 134 patients with VTE separated into 3 groups: (1) ‘low-risk’ patients had ≥1 provoked VTE; (2) ‘moderate-risk’ pa...
ORGANISM(S): Homo sapiens 
2015-11-23 | E-GEOD-48000 | biostudies-arrayexpress
UnknownGastrointestinal pathology in juvenile and adult CFTR-knockout ferrets.
Not available
S-EPMC4005986 | biostudies-literature
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