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Purpose: The goals of this study were to identify quantitative gene expression differences between macrophages derived from wild type and PI3Kgamma null macrophages Methods: mRNA profiles of MCSF, IL4 and IFNg/LPS stimulated macrophage wild-type (WT) and PI3Kinase gamma knockout (p110g-/-) mice wer...
ORGANISM(S): Mus musculus 
Using hydrogen deuterium exchange mass spectrometry, we reveal molecular differences between the two p110g-p84 and p110g-p101 complexes that explain their differential activation.
ORGANISM(S): Homo sapiens (Human) 
2023-03-09 | PXD035723 | Pride
Purpose: The goals of this study were to identify quantitative gene expression differences between macrophages derived from wild type and PI3Kgamma null macrophages Methods: mRNA profiles of MCSF, IL4 and IFNg/LPS stimulated macrophage wild-type (WT) and PI3Kinase gamma knockout (p110g-/-) mice were...
ORGANISM(S): Mus musculus 
2016-07-18 | GSE58318 | GEO
Purpose: The goals of this study were to identify quantitative gene expression differences between whole tumor and tumor-associated macrophages (TAMs) derived from Lewis lung carcinoma (LLC) tumors grown in wild type and PI3Kinase-gamma-null mice. Methods: mRNA profiles of whole tumor or tumor-assoc...
ORGANISM(S): Mus musculus 
2016-08-25 | GSE84535 | GEO
Next Generation Sequencing and Quantitative Analysis of Wild Type and p110gamma-/- macrophages
Next-generation sequencing and quantitative analysis of wild type and p110gamma -/- tumors and tumor-associated macrophages
A Toxoplasma gondii MAF1b - human RalGAPα1 complex highlights a potentially previously uncharacterized immunomodulatory role for MAF1b
ORGANISM(S): Homo sapiens (Human) 
2024-05-22 | PXD034607 | Pride
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