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GenomicsPI3Kg inhibition circumvents inflammation and mortality in SARS-CoV-2 and other infections
PI3Kg inhibition circumvents inflammation and mortality in SARS-CoV-2 and other infections
PRJNA1073955 | ENA
GenomicsPI3Kg in B cells promotes antibody responses and generation of antibody-secreting cells [scRNA-seq]
PI3Kg in B cells promotes antibody responses and generation of antibody-secreting cells [scRNA-seq]
PRJNA1120924 | ENA
GenomicsPI3Kg in B cells promotes antibody responses and generation of antibody-secreting cells [RNA-seq]
PI3Kg in B cells promotes antibody responses and generation of antibody-secreting cells [RNA-seq]
PRJNA1120931 | ENA
ProteomicsMolecular basis for differential activation of p101 and p84 complexes of PI3Kg by Ras and GPCRs
Using hydrogen deuterium exchange mass spectrometry, we reveal molecular differences between the two p110g-p84 and p110g-p101 complexes that explain their differential activation.
ORGANISM(S): Homo sapiens (Human) 
2023-03-09 | PXD035723 | Pride
Pi3kg P101 Ras P110g Hdx-ms Hdx Gby 
TranscriptomicsRNAseq profiling of tumor, tumor-draining-lymph nodes, blood and tumor-associated macrophages of MC38 mice treated with the PI3Kg inhibitor AZD3458 and a combination of AZD3458 and anti-PD-1
RNAseq profiling of AZD3458 monotherapy and combination treatment with anti-PD-1 of whole tumors, isolated tumor macrophages (Mac) (CD45+CD11b+F4/80+), whole blood (PB) and tumor draining lymph nodes (TDLN) were assessed to elucidate further mechanisms leading to enhanced combination activity.
ORGANISM(S): Mus musculus 
2021-02-28 | E-MTAB-10057 | biostudies-arrayexpress
TranscriptomicsPI3Kg inhibition circumvents inflammation and mortality in SARS-CoV-2 and other infections
Virulent infectious agents such as SARS-CoV-2 and Methicillin Resistant Staphylococcus Aureus (MRSA) induce tissue damage that recruits neutrophils and monocyte/macrophages, leading to T cell exhaustion, fibrosis, vascular leak, epithelial cell depletion, and fatal organ damage. Neutrophils, monocyt...
ORGANISM(S): Mus musculus 
2024-03-12 | GSE255211 | GEO
TranscriptomicsEffect of PI3K-gamma inhinition of human Langerhans cells
The potential involvement of PI3Kγ in immune-related diseases has been recently investigated leading to efforts in developing specific inhibitors of this isoform as therapeutic strategies. (Takeda et al 2010, Rommel et al 2007). Of particular significance to cutaneous disease, murine studies have in...
ORGANISM(S): Homo sapiens 
2017-03-30 | GSE94247 | GEO
GenomicsRNAseq profiling of tumor, tumor-draining-lymph nodes, blood and tumor-associated macrophages of MC38 mice treated with the PI3Kg inhibitor AZD3458 and a combination of AZD3458 and anti-PD-1
RNAseq profiling of tumor, tumor-draining-lymph nodes, blood and tumor-associated macrophages of MC38 mice treated with the PI3Kg inhibitor AZD3458 and a combination of AZD3458 and anti-PD-1
PRJEB42741 | ENA
TranscriptomicsPI3Kg in B cells promotes antibody responses and generation of antibody-secreting cells [RNA-seq]
The differentiation of naïve and memory B cells into antibody-secreting cells (ASCs) is a key feature of adaptive immunity. The requirement for phosphoinositide 3-kinase delta (PI3Kδ) to support B cell biology has been investigated intensively; however, specific functions of the related phosphoinosi...
ORGANISM(S): Mus musculus 
2024-06-26 | GSE269303 | GEO
TranscriptomicsPI3Kg in B cells promotes antibody responses and generation of antibody-secreting cells [scRNA-seq]
The differentiation of naïve and memory B cells into antibody-secreting cells (ASCs) is a key feature of adaptive immunity. The requirement for phosphoinositide 3-kinase delta (PI3Kδ) to support B cell biology has been investigated intensively; however, specific functions of the related phosphoinosi...
ORGANISM(S): Mus musculus 
2024-06-26 | GSE269300 | GEO
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