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ProteomicsPptc7 is an essential phosphatase for promoting mammalian mitochondrial metabolism and biogenesis
Mitochondrial proteins are replete with phosphorylation; however, the origin, abundance, and functional relevance of these modifications are largely unclear. Nonetheless, mitochondria possess multiple resident phosphatases, suggesting that protein dephosphorylation may be broadly important for mitoc...
ORGANISM(S): Mus musculus (Mouse) 
2019-05-29 | PXD012743 | Pride
Mitochondia Pptc7 Phosphoproteome 
MetabolomicsThe genetic origin of evolidine, the first cyclopeptide discovered in plants, and related orbitides

Cyclic peptides are reported to have antibacterial, antifungal and other bioactivities. Orbitides are a class of cyclic peptide that are small, head-to-tail cyclized, composed of proteinogenic amino acids, and lack disulfide bonds; they are also known in several genera of the plant family Rutacea...

2020-10-14 | MTBLS1963 | MetaboLights
MetabolomicsPseudomonas sp. Strain 273 Incorporates Organofluorine into the Lipid Bilayer during Growth with Fluorinated Alkanes
Anthropogenic organofluorine compounds are recalcitrant, globally distributed, and a human health concern. Although rare, natural processes synthesize fluorinated compounds, and some bacteria have evolved mechanisms to metabolize organofluorine compounds. Pseudomonas sp. strain 273 grows with...
2022-06-06 | MTBLS3893 | MetaboLights
MetabolomicsProteomic and metabolomic profiling of acute and chronic stress events associated with military exercises.
By characterizing physiological changes that occur in warfighters during simulated combat, we can start to unravel the key biomolecular components that are linked to physical and cognitive performance. Viable field-based sensors for the warfighter must be rapid and noninvasive. In an effort to facil...
2023-12-05 | MTBLS5463 | MetaboLights
MetabolomicsMetabolomic Responses of Arabidopsis Suspension Cells to Bicarbonate under Light and Dark Conditions
Global CO2 level presently recorded at 400 ppm is expected to reach 550 ppm in 2050, an increment likely to impact plant growth and productivity. Using targeted LC-MS and GC-MS platforms we quantified 229 and 29 metabolites, respectively in a time-course study to reveal short-term responses to diffe...
2017-04-25 | MTBLS311 | MetaboLights
ProteomicsPrimary villous trophoblasts exposed to flame retardant BDE-47
We exposed primary villous trophoblasts to flame retardant BDE-47 (1, 5 uM) across three culture time points (15, 24, 39 hr).
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-07-23 | MSV000087870 | MassIVE
ProteomicsGlobal profiling of human cyotrophoblast differentiation/invasion
We profiled purified human cytotrophoblasts derived from second trimester placenta across four culture time points (0-39 h).
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-03-02 | MSV000086970 | MassIVE
ProteomicsHeme biosynthesis regulates BCAA catabolism and thermogenesis in brown adipose tissue
The distinctive color of brown adipose tissue (BAT) is attributed to its high content of heme-rich mitochondria. Despite this, the mechanisms by which BAT regulates intracellular heme levels remain largely unexplored. Here, we demonstrate that heme biosynthesis is the primary source of heme in brown...
ORGANISM(S): Mus musculus (Mouse) 
2025-02-17 | PXD060812 | Pride
Mouse Brown adipose Lc-ms/ms 
ProteomicsPhosphorylation site mapping on purified mGluR8/arrestin complexes
phosphorylation sites of purified mGluR8 with arrestin are mapped by mass spectrometry.
ORGANISM(S): Homo sapiens (Human) 
2026-08-22 | PXD055267 | Pride
Neuronal receptor Gpcr Phosphorylation Metabotropic glutamate receptor 8 
ProteomicsRadical footprinting in mammalian whole blood
Hydroxyl Radical Protein Footprinting (HRPF) is a powerful tool to probe protein higher-order structure, as well as protein-protein and protein-carbohydrate interactions. It is mostly performed in vitro, but recent advances have extended its use to live cells, nematodes, and 3D cultures. However, ap...
ORGANISM(S): Mus musculus (Mouse) 
2026-01-13 | PXD064571 | Pride
Hrpf Targeted analysis Mouse blood Diabetes mellitus 
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