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MetabolomicsUntargeted Metabolomics Reveals a Lack Of Synergy between Nifurtimox and Eflornithine against Trypanosoma brucei
A non-targeted metabolomics-based approach is presented that enables the study of pathways in response to drug action with the aim of defining the mode of action of trypanocides. Eflornithine, a polyamine pathway inhibitor, and nifurtimox, whose mode of action involves its metabolic activation, are ...
2017-06-07 | MTBLS459 | MetaboLights
ProteomicsE. coli BW25113 proteomics in nutrient-rich and minimal medium
E. coli BW25113 growth in a nutrient-rich medium supplemented with 20 proteinogenic amino acid medium was studied and compared to growth in minimal medium. Proteome data from these experiments revealed significant differences in amino acid synthesis and transport proteins that were reduced in the nu...
ORGANISM(S): Escherichia coli 
2020-02-18 | PXD011726 | Pride
E. coli rich medium 
ProteomicsThreonine concentration effect on L. lactis growth
L. lactis was grown in steady-state cultures at specific growth rate 0.2 h-1. The concentration of L-threonine in the growth environment was smoothly increased from 1.24mM to 4mM and proteome measurements were carried out to detect proteins involved in threonine metabolism.
ORGANISM(S): Lactococcus lactis 
2015-03-19 | PXD001602 | Pride
Lactococcus lactis Silac Threonine metabolism 
Proteomicsdecellularized hepatic and renal tissue
we aim to characterize the matrisome landscape of decellularized renal and hepatic tissue
ORGANISM(S): Mus musculus (Mouse) 
2026-10-05 | PXD047802 | Pride
Matrisome Kidney Liver Decm Mice 
Proteomicsdecellularized hepatic and renal tissue
we aim to characterize the matrisome landscape of decellularized renal and hepatic tissue from mice
ORGANISM(S): Mus musculus (Mouse) 
2024-05-07 | PXD049189 | Pride
Matrisome decellularized kidney liver mice 
MetabolomicsA large-scale metabolomics study to harness chemical diversity and explore biochemical mechanisms in ryegrass (UPLC-MS HILIC POS assay)
Perennial ryegrass (Lolium perenne) is integral to temperate pastoral agriculture, which contributes most of the milk and meat production worldwide. Chemical profiles and diversity of ryegrass offer several opportunities to harness specific traits and elucidate underlying biological mechanism...
2019-03-01 | MTBLS62 | MetaboLights
ProteomicsAcclimatization of Methylocystis to inhibitory NH4+ levels by multiple proteomic and metabolic response mechanisms
High NH4+ load is known to competitively inhibit bacterial methane oxidation. This is due to a competition between CH4 and NH4+/NH3 for the active site of particulate methane monooxygenase (pMMO), which converts CH4 to CH3OH. Here, we combined growth experiments with global proteomics to elucidate t...
ORGANISM(S): Methylocystis sp. SC2 
2022-09-19 | PXD032347 | Pride
Methylocystis sp. strain sc2 
MetabolomicsMetabolomic analysis reveals a differential adaptation process of the larval stages of Anisakis simplex to the host environment

Anisakis simplex are parasitic nematodes that cause anisakiasis. The possibility of infection with this parasite is through consumption of raw or undercooked fish products. A. simplex infections are often misdiagnosed, especially in subclinical cases that do not present with typ...

2023-07-08 | MTBLS6458 | MetaboLights
ProteomicsAsparagine uptake: a cellular strategy of Methylocystis to combat severe salt stress
Sodium chloride is an important ionic-osmotic stressor in bulk and rhizosphere soils. Members of the alphaproteobacterial genus Methylocystis are known to have a low salt tolerance (≤ 1.0% NaCl),despite the fact that these methane oxidizers are soil inhabitants. We therefore tested various amino aci...
ORGANISM(S): Methylocystis sp. 
2023-04-28 | PXD038675 | Pride
Lfq Salt stress Methylocystis 
MetabolomicsFecal microbiota transplantation plus anti-PD-1 immunotherapy in advanced melanoma: a phase I trial

Fecal microbiota transplantation (FMT) represents a potential strategy to overcome resistance to immune checkpoint inhibitors in patients with refractory melanoma; however, the role of FMT in first-line treatment settings has not been evaluated. We conducted a multicenter phase I trial combining ...

2025-02-27 | MTBLS711 | MetaboLights
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