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UnknownAn Institutional Approach to Equity and Improvement in Child Health Outcomes.
Not available
S-EPMC11464011 | biostudies-literature
UnknownStructural characterization of Campylobacter jejuni lipooligosaccharide outer cores associated with Guillain-Barre and Miller Fisher syndromes.
Not available
S-EPMC1828588 | biostudies-literature
ProteomicsTargeting APEX2 to the mRNA encoding fatty acid synthase β in yeast identifies proteins that bind and control its translational efficiency in the cell cycle
To understand how the translation of FAS1, encoding fatty acid synthase, peaks late in the cell cycle, we identified proteins that bind the FAS1 transcript in a cell cycle-dependent manner. We used dCas13d-APEX2 fusions to target FAS1 and label nearby proteins, which were then identified by mass spe...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-05-24 | PXD041908 | Pride
Yeast  lc-ms/ms  proximity labeling 
TranscriptomicsHtrA1-dependent proteolysis of TGF-M-NM-2 controls both neuronal maturation and developmental survival
Transforming growth factor-M-NM-2 (TGF-M-NM-2) signalling controls a number of cerebral functions and dysfunctions including synaptogenesis, amyloid-M-NM-2 accumulation, apoptosis and excitotoxicity. Using cultured cortical neurons prepared from either wild type or transgenic mice over-expressing a ...
ORGANISM(S): Homo sapiens 
2008-04-15 | E-GEOD-11162 | biostudies-arrayexpress
ProteomicsQuantitative Proteome Responses to Oncolytic Reovirus in GM-CSF and M-CSF-Differentiated Bone Marrow-Derived Cells
To explore reovirus-macrophage interactions, we performed tandem mass tag (TMT)-based quantitative temporal proteomics on mouse bone marrow-derived macrophages (BMMs) generated with 2 cytokines, M-CSF and GM-CSF, representing anti- and pro-inflammatory macrophages, respectively. We quantified 6,863 ...
ORGANISM(S): Mus musculus (Mouse) 
2020-01-07 | PXD015203 | Pride
Reovirus Cell differentiation Macrophages Oncolytic viruses Antigen presentation/processing Viral defense Quantitative proteomics Anti-viral immune response 
Proteomics4-Oxo-2-nonenal Adductions in Cells
4-Oxo-2-nonenal (ONE) derived from lipid peroxidation modifies nucleophiles and transduces redox signaling by its reactions with proteins. However, the molecular interactions between ONE and complex proteomes and their dynamics in situ remain largely unknown. Here we de-scribe a quantitative chemopr...
ORGANISM(S): Homo sapiens (Human) 
2017-08-25 | PXD007149 | Pride
4-oxo-2-nonenal 
UnknownPhase II Intergroup Trial of Alisertib in Relapsed and Refractory Peripheral T-Cell Lymphoma and Transformed Mycosis Fungoides: SWOG 1108.
Not available
S-EPMC4500834 | biostudies-literature
MetabolomicsVeterinary trypanocidal benzoxaboroles are peptidase-activated prodrugs (T. congolense assay)

Livestock diseases caused by Trypanosoma congolense, T. vivax and T. brucei, collectively known as nagana, are responsible for billions of dollars in lost food production annually. There is an urgent need for novel therapeutics. Encouragingly, promising antitrypanosomal benzoxaboroles are under v...

2020-10-22 | MTBLS1309 | MetaboLights
GenomicsAcetylated histone H3K56 interacts with Oct4 to promote mouse embryonic stem cell pluripotency
The presence of acetylated histone H3K56 in human embryonic stem cells (ESCs) correlates positively with the binding of Nanog, Sox2 and Oct4 (NSO) transcription factors at their target gene promoters. However, the function of H3K56ac there has been unclear. We now report that Oct4 interacts with K56...
ORGANISM(S): Mus musculus 
2013-06-25 | E-GEOD-47387 | biostudies-arrayexpress
ProteomicsRegulation of the stress proteome by SCD1
Cytotoxic stress activates stress-activated kinases, initiates adaptive mechanisms, including the unfolded protein response (UPR) and autophagy, and induces programmed cell death. Fatty acid unsaturation prevents cytotoxic stress but the mechanisms are diffuse. We investigated changes in the proteom...
ORGANISM(S): Mus musculus (Mouse) 
2022-04-06 | PXD025396 | Pride
Autophagy Erad Phospholipid Programmed cell death Upr Stress signaling Monounsaturated fatty acid Mouse fibroblast 
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