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ProteomicsHepatitis Delta Virus histone mimicry drives the recruitment of chromatin remodelers for viral RNA replication
Hepatitis Delta virus (HDV) is a satellite of Hepatitis B virus with a single stranded circular RNA genome. HDV RNA genome synthesis is carried out in infected cells by cellular RNA polymerases with the assistance of the small hepatitis delta antigen (S-HDAg). Here we show that S-HDAg binds the Brom...
ORGANISM(S): Homo sapiens (Human) 
2020-05-27 | PXD016880 | Pride
Short linear interaction motif (slim) Hepatitis delta virus (hdv) Snf2h / smarca-5 Snf2l / smarca¬1 Baz2b associated remodeling factor (brf) Rna polymerase ii (rna pol ii) Histone mimicry Hepatitis b virus (hbv) Bromodomain associated to zinc finger protein 2b (baz2b) 
TranscriptomicsGene expression in the right ventricle of Rattus norvegicus during development of right ventricular heart failure and treatment
Right ventricular heart failure (RVF) associated with pulmonary hypertension (PH) is characterized by a distinct gene expression pattern when compared with functional compensatory hypertrophy. Carvedilol treatment after RVF has been established reduces right ventricle (RV) hypertrophy and improves...
ORGANISM(S): Rattus norvegicus 
2013-05-06 | E-GEOD-42579 | biostudies-arrayexpress
MetabolomicsAntiviral metabolite 3'-Deoxy-3',4'-didehydro-cytidine is detectable in serum and identifies acute viral infections including COVID-19

BACKGROUND: There is a critical need for rapid viral infection diagnostics to enable prompt case identification in pandemic settings and support targeted antimicrobial prescribing.

METHODS: Using untargeted high-resolution liquid chromatography coupled with...

2022-02-10 | MTBLS718 | MetaboLights
UnknownHER2-HER3 Heterodimer Quantification by FRET-FLIM and Patient Subclass Analysis of the COIN Colorectal Trial.
Not available
S-EPMC7492762 | biostudies-literature
UnknownThe HMGB1-RAGE axis mediates traumatic brain injury-induced pulmonary dysfunction in lung transplantation.
Not available
S-EPMC5450936 | biostudies-literature
TranscriptomicsEpigenomic comparison of distinct pluripotent stem cell states reveals a new class of enhancers with roles throughout mammalian development (RNA-seq)
NaM-CM-/ve mouse embryonic stem cells (mESCs) and primed epiblast stem cells (mEpiSCs) represent successive snapshots of pluripotency during embryogenesis. Using transcriptomic and epigenomic mapping, we show that a small fraction of transcripts are differentially expressed between mESCs and mEpiSCs...
ORGANISM(S): Mus musculus 
2014-06-04 | E-GEOD-57403 | biostudies-arrayexpress
ProteomicsTargeting peptidyl-arginine deiminase 4 suppresses SARS-CoV-2 replication and modulates the inflammatory response
This project presents a comprehensive, quantitative proteomics and citrullinome profiling study designed to define how viral infection remodels host protein citrullination and related cellular pathways. The experimental design integrates in vitro and in vivo models of infection, including cultured h...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2026-01-30 | PXD072601 | Pride
Protein arginine deiminase Inflammation Covid Lung Padi4 
TranscriptomicsAge-dependent gene and protein expression following transection of neonatal spinal cord of Monodelphis domestica (South American Grey Short-tailed opossum)
In the present study we investigated the genome and the proteome in the segment of cord rostral to the site of injury following a complete spinal cord transection in opossums at an age when axonal growth across a lesion and substantially normal locomotor development occur (postnatal day 7, P7) and c...
ORGANISM(S): Monodelphis domestica 
2015-02-10 | E-GEOD-54805 | biostudies-arrayexpress
TranscriptomicsAdipocyte Differentiation of Immortalized Human Bone Marrow-derived Stromal Cells is Modulated by microRNA-155, microRNA-221 and microRNA-222
Human bone marrow mesenchymal stromal cells are capable of limited self-renewal and multi-lineage differentiation in vitro. Several studies have demonstrated that microRNAs, post-transcriptional modifiers of protein expression, play crucial roles in the regulation of these complex processes. To gain...
ORGANISM(S): Homo sapiens 
2011-08-22 | E-GEOD-24898 | biostudies-arrayexpress
TranscriptomicsHypoxia-induced modulation of gene expression in human adipocytes - A microarray study
Obesity is characterised by expansion of white adipose tissue, accompanied by an inflamatory response. It has been proposed that the inflammatory state observed may be linked to relative hypoxia in clusters of adipocytes distant from vasculature. Adipose tissue hypoxia has been observed in both an...
ORGANISM(S): Homo sapiens 
2012-03-09 | E-GEOD-34007 | biostudies-arrayexpress
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