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ProteomicsA cyclic peptide toolkit reveals mechanistic principles of peptidylarginine deiminase IV (PADI4) regulation
Deregulation of the peptidylarginine deiminase PADI4 promotes the development of autoimmunity, cancer, atherosclerosis and age-related tissue fibrosis. Genetic or pharmacological PADI4 inhibition is therapeutically efficacious in mice but no clinically relevant inhibitors exist to date. PADI4 additi...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-06 | PXD048807 | Pride
Deiminase Cyclic-peptide Modulator Padi4 
TranscriptomicsTranscriptional profiling of PADI4 overexpression and inhibition in mouse embryonic stem cells
The enzymatic activity of PADI4 was investigated by overexpression and chemical inhibition to determine the effects of arginine citrullination on histone displacement, reprogramming efficiency and the maintenance of pluripotent stem cells.
ORGANISM(S): Mus musculus 
2013-11-22 | E-MTAB-1975 | biostudies-arrayexpress
ProteomicsThe citrullinating enzyme PADI4 governs progenitor cell proliferation and translation in developing hair follicles
Posttranslational protein modifications have emerged as a mechanism regulating progenitor cell state transitions during tissue formation. Herein, we exploit the stereotyped hair follicle development to delineate the function of PADI4; an enzyme converting peptidylarginine to citrulline. Single cell-...
ORGANISM(S): Mus musculus (Mouse) 
2025-07-28 | PXD064137 | Pride
Mouse Hair follicle Citrullination Padi4 
TranscriptomicsPADI4 ChIP-chip from MCF-7 cells
Peptidylarginine deiminase IV (PADI4) catalyzes the conversion of positively charged arginine and methylarginine residues to neutrally charged citrulline residues on histone tails. This activity has been linked to the repression of gene transcription on a limited number of genes. To broaden our know...
ORGANISM(S): Homo sapiens 
2011-03-31 | E-GEOD-18755 | biostudies-arrayexpress
ProteomicsA quantitative and site-specific atlas of the PADI4-induced citrullinome reveals widespread existence of citrullination
Citrullination refers to the conversion of arginine into the non-essential amino acid citrulline. Despite its importance in physiology and disease, global identification of citrullinated proteins and modification sites has remained challenging. Here, we combined quantitative mass spectrometry-based ...
ORGANISM(S): Homo sapiens (Human) 
2024-01-16 | PXD038702 | Pride
Citrullination Deamination Gsk-484 Hl60 Padi Padi4 
GenomicsSingle-cell sequencing WT and PADI4 cKO skin, P1
Single-cell sequencing WT and PADI4 cKO skin, P1
PRJNA1216231 | ENA
TranscriptomicsPADI4 acts as a coactivator of Tal1 by counteracting repressive histone arginine methylation at the IL6ST (gp130) promoter
Analysis of common genes regulated by Tal1 and PADI4 2 controls + 2x3 knockdown samples HEL cells were transduced with lentiviruses harboring shconstructs against the transcription factor Tal1 and PADI4 respectively, in biological triplicates. Two control samples with a control lentivirus with an sh...
ORGANISM(S): Homo sapiens 
2014-06-02 | E-GEOD-54075 | biostudies-arrayexpress
UnknownPADI4 and tumourigenesis.
Not available
S-EPMC2845578 | biostudies-literature
GenomicsPADI4-mediated citrullination of histone H3 stimulates HIV-1 transcription
PADI4-mediated citrullination of histone H3 stimulates HIV-1 transcription
PRJNA1143570 | ENA
GenomicsPADI4 ChIP-chip from MCF-7 cells
Peptidylarginine deiminase IV (PADI4) catalyzes the conversion of positively charged arginine and methylarginine residues to neutrally charged citrulline residues on histone tails. This activity has been linked to the repression of gene transcription on a limited number of genes. To broaden our know...
ORGANISM(S): Homo sapiens 
2011-03-31 | GSE18755 | GEO
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