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MetabolomicsLipidomic analysis of Toxoplasma gondii extracellular vesicles across host cell types

Introduction. Toxoplasma gondii is an obligate intracellular parasite with an exceptional capacity to colonize a broad range of host species and cell types. Successful infection depends on its ability to manipulate host metabolism, including lipid pathways that are essential for membrane biogenes...

2026-02-11 | MTBLS13253 | MetaboLights
ProteomicsMitochondrial damage drives T-cell immunometabolic paralysis after major surgery
Cytotoxic T cell (CTL) dysfunction is a key feature of immune paralysis following major surgery, significantly increasing the risk of severe nosocomial infections and contributing to elevated mortality in critically ill patients. The pathomechanisms of CTL dysfunction remain unclear. We report that ...
ORGANISM(S): Homo sapiens (Human) 
2025-12-09 | PXD060723 | Pride
TranscriptomicsRibosome profiling of Mycobacterium tuberculosis under nutrient starvation
We have performed parallel ribosome profiling and RNA sequencing to determine which mRNAs are being translated during exponential growth and following 24 hours of nutrient starvation in the human pathogen Mycobacterium tuberculosis.
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2021-02-02 | E-MTAB-8835 | biostudies-arrayexpress
ProteomicsAn Analysis of Toxoplasma gondii Extracellular Vesicles.
Toxoplasma gondii, the causative agent of toxoplasmosis, infects roughly one-third of the global population, highlighting its remarkable adaptability and pathogenicity across a wide range of warm-blooded animals. A key aspect of T. gondii’s ability to interact with its hosts involves the secretion o...
ORGANISM(S): Toxoplasma gondii RH 
2025-03-19 | PXD055601 | Pride
Toxoplasma gondii  exovesicles  evs 
MetabolomicsCascading effects of root microbial symbiosis on the development and metabolome of the insect herbivore Manduca sexta L

Root mutualistic microbes can modulate the production of plant secondary metabolites affecting plant–herbivore interactions. Still, the main mechanisms underlying the impact of root mutualists on herbivore performance remain ambiguous. In particular, little is known about how changes in the plant...

2023-09-12 | MTBLS2700 | MetaboLights
ProteomicsThe impact of culture conditions on E. coli acetylome and proteome
A proteome and acetylome study under different culture conditions was carried out by quantitative label-free mass spectrometry analysis. E. coli K12 BW25113 strain was grown employing TB7 complex medium or M9 minimal medium, supplemented with glucose 20 mM or glycerol 40 mM as carbon source. Therefo...
ORGANISM(S): Escherichia coli Bacteria 
2024-05-21 | PXD041209 | Pride
E. coli Lc-ms Ptm Lysine acetylation Fluxes Metabolism regulation 
ProteomicsProteomic analysis of extracellular vesicles and conditioned medium from human Adipose-derived Stem/Stromal Cells and Dermal Fibroblasts
Conditioned medium (CM) and extracellular vesicles (EV) from human Adipose-derived Stem/stromal cells (ASC) and Dermal fibroblasts (DF) can represent valid cell substitutes in regenerative medicine and other therapeutic applications. Whether one of the two cell products should be preferred over the ...
ORGANISM(S): Homo sapiens (Human) 
2020-12-23 | PXD020219 | Pride
Adipose-derived stromal cells Label-free quantitative proteomics Extracellular vesicles Dermal fibroblasts Conditioned medium Secretome 
ProteomicsCompound interaction screen on a photoactivatable cellulose membrane (CISCM) identifies drug targets
Here, we present a compound interaction screen on a photoactivatable cellulose membrane (CISCM) that enables target identification of several drugs in parallel. To this end, we use diazirine-based undirected photoaffinity labeling (PAL) to immobilize compounds on cellulose membranes. Functionalized ...
ORGANISM(S): Homo sapiens (Human) 
2022-10-25 | PXD033050 | Pride
Human affinity purification-mass spectrometry samples 
TranscriptomicsBulk RNA-seq of Drosophila melanogaster expressing C9orf72 and the associated dipeptide repeat proteins (poly-GA36, poly-GR36, and poly-PR36)
Intronic hexanucleotide repeat expansions in the C9orf72 gene are the most common genetic cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). These intronic hexanucleotide repeat expansions result in the production of toxic dipeptide repeat proteins (DPRs), which contribu...
ORGANISM(S): Drosophila melanogaster 
2026-05-24 | E-MTAB-16995 | biostudies-arrayexpress
TranscriptomicsMYOC.WTvsNull
Comparison of human trabecular meshwork transcriptomes of cells overexpressing wild-type Myocilin
ORGANISM(S): Homo sapiens 
2012-10-06 | E-MEXP-3440 | biostudies-arrayexpress
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