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TranscriptomicsBiological changes in C57BL/6 mice following 3 weeks of inhalation exposure to cigarette smoke or e-vapor aerosols
We compared early biological changes in mice after inhalation exposures to cigarette smoke or e-vapor aerosols (MarkTen® cartridge with Carrier, Test-1, or Test-2 formulations; 4% nicotine). Female C57BL/6 mice were exposed to 3R4F cigarette smoke or e-vapor aerosols by nose-only inhalation for up t...
ORGANISM(S): Mus musculus 
2021-02-28 | E-MTAB-10166 | biostudies-arrayexpress
MetabolomicsAn ancient residue metabolomics-based method to distinguish use of closely related plant species in ancient pipes

Residues from ancient artifacts can help identify which plant species were used for their psychoactive properties, providing important information regarding the deep-time co-evolutionary relationship between plants and humans. However, relying on the presence or absence of one or several biomarke...

2020-07-21 | MTBLS890 | MetaboLights
MetabolomicsA profile of the joint Toxoplasma-host infection metabolome finds broad changes to metabolism and discovers a novel parasite metabolic capability
The obligate intracellular parasite Toxoplasma gondii is auxotrophic for several key metabolites and must scavenge these, and carbon sources like glucose. from the host. While the importance of metabolism to Toxoplasma infection it obvious, it is unclear how Toxoplasma infection actually changes met...
2019-05-10 | MTBLS899 | MetaboLights
UnknownA real time chemotaxis assay unveils unique migratory profiles amongst different primary murine macrophages.
Not available
S-EPMC3597586 | biostudies-literature
UnknownStem cell treatment for acute myocardial infarction.
Not available
S-EPMC8572033 | biostudies-literature
MetabolomicsBiochemical Profiling of the Brain and Blood Metabolome in a Mouse Model of Prodromal Parkinson’s Disease Reveals Distinct Metabolic Profiles (MS assays)
Parkinson’s disease is the second most common neurodegenerative disease. In the vast majority of cases the origin is not genetic and the cause is not well understood, although progressive accumulation of α-synuclein aggregates appears central to the pathogenesis. Currently, treatments that slow dise...
2019-02-07 | MTBLS674 | MetaboLights
MetabolomicsBiochemical Profiling of the Brain and Blood Metabolome in a Mouse Model of Prodromal Parkinson’s Disease Reveals Distinct Metabolic Profiles (NMR assay)
Parkinson’s disease is the second most common neurodegenerative disease. In the vast majority of cases the origin is not genetic and the cause is not well understood, although progressive accumulation of α-synuclein aggregates appears central to the pathogenesis. Currently, treatments that slow dise...
2019-02-07 | MTBLS640 | MetaboLights
ProteomicsProteomic analysis of melanoma resistant cells transfected with siRNA targeting DDR2 or treated with DDR2 inhibitor or Dasatinib
Combined therapy with anti-BRAF plus anti-MEK is currently used as first-line treatment of patients with metastatic melanomas harboring the somatic BRAF V600E mutation. However, the main issue with targeted therapy is the acquisition of tumor cell resistance. In 70% of resistant melanoma cells, the ...
ORGANISM(S): Homo sapiens (Human) 
2023-05-02 | PXD028292 | Pride
Resistance Quantitative proteome Melanoma Discoidin domain receptors 
MetabolomicsImmunomodulatory fecal metabolites are associated with mortality in COVID-19 patients with respiratory failure
Respiratory failure and mortality from COVID-19 result from virus- and inflammation-induced lung tissue damage. The intestinal microbiome and associated metabolites are implicated in immune responses to respiratory viral infections, however their impact on progression of severe COVID-19 remains uncl...
2023-05-02 | MTBLS5288 | MetaboLights
UnknownLactate signalling leads to aggregation of immune-inflammatory hotspots and SLC5A12 blockade promotes their resolution.
Not available
S-EPMC12373510 | biostudies-literature
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