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MetabolomicsUntargeted metabolomics profiling to determine FITM2-dependent metabolic rewiring under IFNγ stimulation
This study aimed to define metabolic alterations associated with FITM2 loss in tumor cells exposed to inflammatory cytokine signaling. KPC control and FITM2 knockout cells were treated with IFNγ and subjected to untargeted metabolomics profiling using LC–MS/MS. Data from positive and negative ioniza...
2026-04-11 | MTBLS14254 | MetaboLights
MetabolomicsFitm2 is required for ER homeostasis and normal function of murine liver
Not available
ORGANISM(S): Mus musculus 
ST002303 | MetabolomicsWorkbench
ProteomicsFitm2 is required for ER homeostasis and normal function of murine liver
The ER-resident prote in fat-inducing transcript 2 (FIT2) catalyzes acyl-CoA cleavage in vitro, and in cells is required for endoplasmic reticulum (ER)homeostasis and normal lipid storage. The gene encoding FIT2 is essential for viability of mice and worms. Whether FIT2 acts as anacyl-CoA diphosphat...
ORGANISM(S): Mus musculus (Mouse) 
2023-05-10 | PXD033884 | Pride
Lipid metabolism Acyl-coa Endoplasmic reticulum Liver Fitm2 
UnknownA homozygous FITM2 mutation causes a deafness-dystonia syndrome with motor regression and signs of ichthyosis and sensory neuropathy.
Not available
S-EPMC5312003 | biostudies-literature
UnknownThe first case of deafness-dystonia syndrome due to compound heterozygous variants in FITM2.
Not available
S-EPMC6132111 | biostudies-literature
UnknownFITM2 deficiency results in ER lipid accumulation, ER stress, and reduced apolipoprotein B lipidation and VLDL triglyceride secretion in vitro and in mouse liver.
Not available
S-EPMC11574801 | biostudies-literature
UnknownFitm2 is required for ER homeostasis and normal function of murine liver.
Not available
S-EPMC10027564 | biostudies-literature
TranscriptomicsInflammatory cytokines induce novel cancer dependencies
Tumor cells respond and adapt to environmental stresses, including cytokine-mediated inflammation, to facilitate growth in hostile environments. However, cytokine responses also induce transcriptional and cell state changes that may predispose tumor cells to new vulnerabilities, which remain largely...
ORGANISM(S): Mus musculus 
2025-09-04 | GSE269110 | GEO
TranscriptomicsSaturated fatty acids promotes β-cell toxicity by disabling intracellular lipid droplet formation through S-acylation of FIT2
Palm and coconut oils are linked to cardiovascular disease and diabetes because of their high saturated fatty acid (SFA) content but exactly how exogenous SFAs, but not unsaturated fatty acids (UFA), are toxic to cells remains unknown. In insulin-producing, β-cells of the Islets of Langerhans, loss ...
ORGANISM(S): Mus musculus 
2021-07-08 | GSE133939 | GEO
UnknownCoordinated inhibition of M1 macrophage polarization by FIT2-mediated lipid droplet biosynthesis and FABP5.
Not available
S-EPMC12780504 | biostudies-literature
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