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MetabolomicsMultiple acyl-coA dehydrogenase deficiency kills Mycobacterium tuberculosis in vitro and during infection

The human pathogen Mycobacterium tuberculosis (Mtb) devotes a significant fraction of its genome to fatty acid metabolism. Although Mtb depends on host fatty acids as a carbon source, fatty acid b-oxidation is mediated by genetically redundant enzymes, which has hampered the development of antitu...

2021-09-29 | MTBLS2374 | MetaboLights
MetabolomicsMetabolomic profiling of Streptomyces coelicolor overexpressing the alpha subunit of acyl-CoA carboxylase
This study contains metabolomics data from Streptomyces coelicolor M145 overexpressing the alpha subunit of acyl-CoA carboxylase. The data were generated to investigate metabolite changes associated with alpha subunit overexpression and to explore its effects on primary metabolism, acyl-CoA precurso...
2026-05-06 | MTBLS14439 | MetaboLights
MetabolomicsMetabolomic profiling of Streptomyces virginiae overexpressing the alpha subunit of acyl-CoA carboxylase
This study contains metabolomics data from Streptomyces virginiae CGMCC 4.1619 overexpressing the alpha subunit of acyl-CoA carboxylase. The data were generated to investigate metabolite changes associated with alpha subunit overexpression and to explore its effects on primary metabolism, acyl-CoA p...
2026-05-06 | MTBLS14442 | MetaboLights
MetabolomicsMetabolomic profiling of Kitasatospora aureofaciens overexpressing the alpha subunit of acyl-CoA carboxylase
This study contains metabolomics data from Kitasatospora aureofaciens ATCC 10762 overexpressing the alpha subunit of acyl-CoA carboxylase. The data were generated to investigate metabolite changes associated with alpha subunit overexpression and to explore its effects on primary metabolism, acyl-CoA...
2026-05-06 | MTBLS14444 | MetaboLights
MetabolomicsMetabolomic profiling of Streptomyces ambofaciens overexpressing the alpha subunit of acyl-CoA carboxylase

This study contains metabolomics data from Streptomyces ambofaciens CGMCC 4.1528 overexpressing the alpha subunit of acyl-CoA carboxylase. The data were generated to investigate metabolite changes associated with alpha subunit overexpression and to explore its effects on primary metabolism, acyl-...

2026-05-06 | MTBLS14441 | MetaboLights
MetabolomicsTranscript variants of long-chain acyl-CoA synthase 1 have distinct roles in sheep lipid metabolism
Mutton has recently been identified to be a consumer favorite, and intermuscular fat is the key factor in determining meat tenderness. Long-chain acyl-CoA synthetase 1 (ACSL1) is a vital subtype of the ACSL family that is involved in the synthesis of lipids from acyl-CoA and the oxidation of fatty a...
2023-02-06 | MTBLS5808 | MetaboLights
TranscriptomicsDisturbed Hepatic Carbohydrate Management During High Metabolic Demand in Medium-Chain Acyl-CoA Dehydrogenase (MCAD)-deficient Mice
Medium-chain acyl-coenzyme A (CoA) dehydrogenase (MCAD) catalyzes crucial steps in mitochondrial fatty acid oxidation, a process that is of key relevance for maintenance of energy homeostasis, especially during high metabolic demand. To gain insight into the metabolic consequences of MCAD defici...
ORGANISM(S): Mus musculus 
2012-04-25 | E-GEOD-37546 | biostudies-arrayexpress
TranscriptomicsKnockout of the Acyl CoA binding protein (ACBP) in mice - expression profile from the liver of 21 days old ACBP-/- and +/+ mice.
The ACBP knockout were created by targeted disruption of the gene in mice. The expression profiling was performed on liver tissue from ACBP-/- (KO) and +/+ (WT) mice at the age of 21 days, which in our study is the time immediately before weaning. The mice used for this experiment were taken directl...
ORGANISM(S): Mus musculus 
2010-11-26 | E-GEOD-24451 | biostudies-arrayexpress
TranscriptomicsRNAi knock down of Enigma, a mitochondrial protein with homology to acyl-CoA dehydrogenases, in Drosophila
5 day RNAi treatment to knockdown Enigma, CG9006, a Drosophila mitochondrial protein with homology to acyl-CoA dehydrogenases. Experiment Overall Design: Kc-167 cells, 5 day treatment with Enigma-specific RNAi or beta-lactamase control RNAi. Specifics:1.6X10^6 cells in 0.5mL of serum-free Sang's M3 ...
ORGANISM(S): Drosophila melanogaster 
2007-07-31 | E-GEOD-3566 | biostudies-arrayexpress
ProteomicsA systems chemoproteomic analysis of acyl-CoA signaling networks
Acyl-CoAs are essential for life. These metabolites serve as fundamental cellular building blocks in the biosynthesis of lipids, intermediates in energy production via the TCA cycle, and essential precursors for reversible protein acetylation. Each of these roles are dependent on acyl-CoA/protein in...
ORGANISM(S): Homo sapiens (Human) 
2019-11-21 | PXD013157 | Pride
Proteomics Acetyltransferase Mudpit Acyl-coa 
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