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TranscriptomicsLong non-coding RNAs act as novel mediators of Innate Immunity
Recent advances in genome technologies have uncovered thousands of long non-coding RNAs (lncRNAs) whose function in the immune system has been largely unexplored. Members of the Toll-like receptor (TLR) family activate an inducible program of inflammatory genes important in host defenses. Here we p...
ORGANISM(S): Mus musculus 
2013-08-26 | E-GEOD-40978 | biostudies-arrayexpress
TranscriptomicsThe transcriptional repressor BLIMP1 curbs host-defenses by suppressing expression of the chemokine CCL8
The transcriptional repressor BLIMP1 is a master regulator of B and T cell differentiation. To examine the role of BLIMP1 in innate immunity we used a conditional knockout (CKO) of Blimp1 in myeloid cells and found that Blimp1 CKO mice were protected from lethal infection induced by Listeria monocyt...
ORGANISM(S): Mus musculus 
2013-12-10 | E-GEOD-53145 | biostudies-arrayexpress
TranscriptomicsA host type I interferon response is induced by cytosolic sensing of the bacterial second messenger cyclic-di-GMP
The innate immune system responds to unique molecular signatures that are widely conserved among microbes but that are not normally present in host cells. Compounds that stimulate innate immune pathways may be valuable in the design of novel adjuvants, vaccines, and other immunotherapeutics.The cyc...
ORGANISM(S): Mus musculus 
2009-07-21 | E-GEOD-16943 | biostudies-arrayexpress
UnknownLife-Threatening Complications of Influenza vs Coronavirus Disease 2019 (COVID-19) in US Children.
Not available
S-EPMC9384330 | biostudies-literature
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