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GenomicsCUT&Tag seq of control, FK866-, FK866 plus succinate-treated ILC2s in vitro
CUT&Tag seq of control, FK866-, FK866 plus succinate-treated ILC2s in vitro
PRJNA1086184 | ENA
TranscriptomicsMolecular sequelae of Nampt Inhibition in Human Multiple Myeloma cell line
Evaluation of specific coordinated pattern of transcriptional events consistent with anti-myeloma activity of FK866 (chemical Nampt inhibitor) 3 samples were analyzed using as control the untreated cells. Treated cells were cultured in presence of FK866 at concentration of 10nM for 6 and 24 hours.
ORGANISM(S): Homo sapiens 
2012-11-05 | E-GEOD-35414 | biostudies-arrayexpress
TranscriptomicsTranslatome and transcriptome profiling of FK866 response in Jurkat cells
We treated Jurkat cells for 48 hr with a sublethal dose of FK866 (5 nM) and DMSO (Mock, control treatment). RNA samples for microarrays derived from fractionated samples by sucrose gradient (sub-polysomes, polysomes), giving us the chance to perform an analysis among polysomal/subpolysomal distribu...
ORGANISM(S): Homo sapiens 
2015-04-01 | E-GEOD-53772 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of mouse pancreatic islets treated with cytokines and NAMPT inhibitor (FK866)
Type 1 diabetes (T1D) is characterised by destruction of pancreatic beta cells by islet-infiltrating cytotoxic lymphocytes, and elevated intra-islet secretion of pro-inflammatory cytokines. We hypothesise that abnormal elevation of islet NAD, via activation of NAMPT, plays a key role in driving isle...
ORGANISM(S): Mus musculus 
2025-11-22 | E-MTAB-12382 | biostudies-arrayexpress
ProteomicsYAP modulates mitochondrial function and sensitive to NAMPT inhibition in triple negative breast cancer cells
YAP and TAZ coordinate several NAD+-dependent processes like glycolysis, fatty acid oxidation and glutaminolysis in nutrient-deprivation conditions. However, correlations between NAD(H) levels and YAP/TAZ metabolic function are still poorly understood. We showed that stable silencing of YAP in the t...
ORGANISM(S): Homo sapiens (Human) 
2025-02-24 | PXD046817 | Pride
Mitochondrial fitness Metabolic adaptation Yap Drug resistance Fk866 Cell cycle Nad(h) 
OtherCUT&Tag seq of control, FK866-, FK866 plus succinate-treated ILC2s in vitro
To investigate the effect of NAD+ metabolism on ILC2s, sorted ILC2s from the gut were treated with FK866 or FK866 plus succinate for CUT-Tag sequcecing.
ORGANISM(S): Mus musculus 
2024-03-12 | GSE261263 | GEO
GenomicsRNA-seq of control and FK866-treated ILC2s in vitro
RNA-seq of control and FK866-treated ILC2s in vitro
PRJNA903374 | ENA
GenomicsThe NAMPT inhibitor FK866 increases metformin sensitivity in pancreatic cancer cells
The NAMPT inhibitor FK866 increases metformin sensitivity in pancreatic cancer cells
PRJNA866164 | ENA
TranscriptomicsTranscriptome profiling of FK866 response in CCRF-CEM parental and resistant cells
Parental and resistant CCRF-CEM cells were treated for 48 hr with a sublethal dose of FK866 (5 nM) or DMSO (Mock, control treatment). This comparison enables the identification of the specific transcriptional alterations induced by FK866 in parental or resistant cells. Keywords: transcriptome profil...
ORGANISM(S): Homo sapiens 
2018-03-14 | GSE96636 | GEO
TranscriptomicsTranslatome and transcriptome profiling of FK866 response in Jurkat cells
We treated Jurkat cells for 48 hr with a sublethal dose of FK866 (5 nM) and DMSO (Mock, control treatment). RNA samples for microarrays derived from fractionated samples by sucrose gradient (sub-polysomes, polysomes), giving us the chance to perform an analysis among polysomal/subpolysomal distribut...
ORGANISM(S): Homo sapiens 
2015-04-01 | GSE53772 | GEO
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