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MetabolomicsSelective mTOR inhibition via FLCN drives TFE3-dependent VLDL-TG secretion and protects from MAFLD/MASH
Hepatic lipid homeostasis is controlled by multiple processes, including VLDL-TG secretion. We have previously shown that the FLCN/TFE3 branch of mTORC1 signaling controls hepatic fatty acid oxidation and de novo lipogenesis to protect mice from MAFLD. We now show that the FLCN/TFE3 pathway also con...
2026-09-08 | MTBLS15598 | MetaboLights
ProteomicsPhosphoproteomic analysis of the Folliculin (FLCN) tumor suppressor reveals FLCN-dependent kinase signaling and TFEB regulation
In Birt-Hogg-Dubé (BHD) syndrome, germline mutations in the Folliculin (FLCN) gene lead to an increased risk of renal cancer. To address if FLCN is involved regulating cellular signaling pathways via protein and receptor phosphorylation we determined comprehensive complete phosphoproteomic profiles ...
ORGANISM(S): Homo sapiens (Human) 
2022-07-11 | PXD025798 | Pride
Folliculin Flcn Renal cell carcinoma Phosphoproteomics Signaling Ptyr ip Inka 
TranscriptomicsGene expression profiling of BHDS-associated renal tumors
Renal tumors that arise in individuals with BHD Syndrome represent a molecularly distinct form of renal cancer. In addition, BHD syndrome is due to a mutation the folliculin gene (FLCN). While the folliculin gene is an important tumor suppressor gene, the molecular function of this gene is not well...
ORGANISM(S): Homo sapiens 
2010-12-21 | E-GEOD-21816 | biostudies-arrayexpress
ProteomicsThe Tumor Suppressor FLCN Regulates Glycolysis by Specifically Binding and Inhibiting Lactate Dehydrogenase-A
The “Warburg effect” describes the use of aerobic glycolysis by cancer cells to fuel their growth. Lactate dehydrogenase-A (LDHA) is key to this process and catalyzes the interconversion of pyruvate and lactate. Here we used a proteomic approach to identify LDHA as a binding partner of the tumor sup...
ORGANISM(S): Homo sapiens (Human) 
2021-08-05 | PXD018410 | Pride
Flcn ldha glycolysis 
ProteomicsLoss of FLCN-FNIP1/2 Induces a Non-Canonical Interferon 1 Response in Human Renal Tubular Epithelial Cells
Germline inactivating mutations in Folliculin (FLCN) cause Birt–Hogg–Dubé (BHD) syndrome, a rare autosomal dominant disorder predisposing to kidney tumors. FLCN is a conserved, essential gene that has been linked to diverse cellular processes but the mechanisms by which FLCN prevents kidney cancer r...
ORGANISM(S): Homo sapiens (Human) 
2021-02-11 | PXD021346 | Pride
Flcn Folliculin Bhd Human Kidney Birt–hogg–dubé syndrome 
GenomicsMouse liver FLCN gRNA on high fat/high fructose diet
Mouse liver FLCN gRNA on high fat/high fructose diet
PRJNA1463790 | ENA
TranscriptomicsGene expression data from FLCN-restored UOK257-2 renal cancer cells
UOK257 cell line was derived from a BHD patient. It harbors a germline mutation in FLCN (c.1285dupC) and LOH. UOK257-2 cells were generated from UOK257 cells by introducing wildtype FLCN using retrovirus. FLCN inactivation induces TFE3 transcriptional activity by increasing its nuclear localization....
ORGANISM(S): Homo sapiens 
2010-10-11 | E-GEOD-23614 | biostudies-arrayexpress
GenomicsFLCN Gene Ablation Reduces Fibrosis and Inflammation in a Diet-Induced NASH Model
FLCN Gene Ablation Reduces Fibrosis and Inflammation in a Diet-Induced NASH Model
PRJNA659508 | ENA
TranscriptomicsFlcn and BHD renal tumorigenesis
Targeted disruption of Flcn in mouse kidney proximal tubule gives insights into human BHD renal tumorigenesis Mouse Tumor kidney tissue vs. normal kidney tissue
ORGANISM(S): Mus musculus 
2014-07-28 | E-GEOD-49397 | biostudies-arrayexpress
GenomicsHeLa-FLCN KO upon Trametinib treatment [Trametinib_RNAseq]
HeLa-FLCN KO upon Trametinib treatment [Trametinib_RNAseq]
PRJNA862893 | ENA
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