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GenomicsFolliculin deficiency effect on Raw264.7 cells
Folliculin deficiency effect on Raw264.7 cells
PRJNA473700 | ENA
ProteomicsPhosphoproteomcs of the folliculin negative cancer cell line UOK257 +/- lentiviral rescue construct
In Birt-Hogg-Dubé (BHD) syndrome, germline mutations in the Folliculin (FLCN) gene lead to an increased risk of renal cancer. To address if FLCN is involved regulating cellular signaling pathways via protein and receptor phosphorylation we determined comprehensive phosphoproteomic profiles of FLCN-P...
ORGANISM(S): Homo sapiens (Human) 
2022-07-11 | PXD030237 | Pride
Flcn Folliculin Imac Single shot Ptyrip Phosphoproteomics Label free 
UnknownFolliculin mutations are not associated with severe COPD.
Not available
S-EPMC2636779 | biostudies-literature
TranscriptomicsGene expression profiling of BHDS-associated renal tumors
Renal tumors that arise in individuals with BHD Syndrome represent a molecularly distinct form of renal cancer. In addition, BHD syndrome is due to a mutation the folliculin gene (FLCN). While the folliculin gene is an important tumor suppressor gene, the molecular function of this gene is not well...
ORGANISM(S): Homo sapiens 
2010-12-21 | E-GEOD-21816 | biostudies-arrayexpress
UnknownCrystal structure of folliculin reveals a hidDENN function in genetically inherited renal cancer.
Not available
S-EPMC3438538 | biostudies-literature
TranscriptomicsFolliculin deficiency effect on Raw264.7 cells
Osteoclast differentiation is a dynamic differentiation process, which is accompanied by dramatic changes in metabolic status as well as in gene expression. Recent findings have revealed an essential connection between metabolic reprogramming and dynamic gene expression changes during osteoclast dif...
ORGANISM(S): Mus musculus 
2018-07-30 | GSE115084 | GEO
GenomicsFolliculin regulates mTORC1/2 and WNT pathways in early human pluripotency
Folliculin regulates mTORC1/2 and WNT pathways in early human pluripotency
PRJNA503630 | ENA
ProteomicsFolliculin regulates mTORC1/2 and WNT pathways in early human pluripotency
Using co-immunoprecipitation and mass spectrometry analysis we identify unique FLCN binding partners. The interactions of FLCN with components of the mTOR pathway (mTORC1 and mTORC2) reveal a mechanism of FLCN function during exit from naïve pluripotency.
ORGANISM(S): Homo sapiens (Human) 
2019-02-13 | PXD011736 | Pride
Folliculin Mtor 
TranscriptomicsThe Folliculin-Fnip1 pathway deleted in human Birt-Hogg-Dube syndrome is required for B cell development.
Birt-Hogg-Dube (BHD) syndrome is an autosomal dominant disorder characterized by hamartomas of skin follicles, cystic lung disease, and renal neoplasia. Affected individuals carry heterozygous mutations in Folliculin (FLCN), a tumor suppressor gene that becomes biallelically inactivated in kidney t...
ORGANISM(S): Mus musculus 
2012-06-16 | E-GEOD-38741 | biostudies-arrayexpress
TranscriptomicsThe Folliculin-Fnip1 pathway deleted in human Birt-Hogg-Dube syndrome is required for B cell development.
Birt-Hogg-Dube (BHD) syndrome is an autosomal dominant disorder characterized by hamartomas of skin follicles, cystic lung disease, and renal neoplasia. Affected individuals carry heterozygous mutations in Folliculin (FLCN), a tumor suppressor gene that becomes biallelically inactivated in kidney tu...
ORGANISM(S): Mus musculus 
2012-06-16 | GSE38741 | GEO
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