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UnknownDynamic mechanical stimulation of alveolar epithelial-fibroblast models using the Flexcell tension system to study of lung disease mechanisms.
Not available
S-EPMC12401065 | biostudies-literature
TranscriptomicsComparison of human aortic valve interstitial cells (AVICs) exposed to cyclic stretch to static samples
AVICs were exposed to cyclic stretch to examine the role of mechanical stimuli on gene expression AVICs cultured on collagen 1 coated Bioflex were exposed to 14% stretch at 1 hz or static conditions using a Flexcell-5000 14% stretch was the experimental condition while the static condition was the c...
ORGANISM(S): Homo sapiens 
2015-01-09 | E-GEOD-47687 | biostudies-arrayexpress
TranscriptomicsExcessive mechanical strain accelerates intervertebral disc degeneration by disrupting the intrinsic circadian rhythm
Nucleus pulposus cells were stretched using a FX-5000T Flexcell tension plus system (Flexcell International Corp., USA) with 18% elongation (0.2 Hz) for 24 h
ORGANISM(S): Rattus norvegicus 
2021-05-28 | GSE175710 | GEO
ProteomicsPrimary Human MSCs subjected to 1 hr intense cyclic tensile strain with/without 24 hr recovery
Cells resident in tissues must be resilient to the physical demands of their surroundings. Our current understanding of cellular mechano-signalling is largely based on static systems, but these models do not reproduce the dynamic nature of living tissue. Here, we examined the time-resolved response ...
ORGANISM(S): Homo sapiens (Human) 
2019-04-24 | PXD012949 | Pride
Strain Msc Flexcell 
TranscriptomicsThe human airway epithelial basal cell transcriptome in the early response to injury
Background: Basal cells within the human airway epithelium constitute the stem/progenitor cells for other epithelial cell types. Basal cells respond to mucosal injury and damage to the airway mucosa in an ordered sequence of spreading, migration, proliferation and phenotype shifting (differentiation...
ORGANISM(S): Homo sapiens 
2015-04-30 | E-GEOD-59128 | biostudies-arrayexpress
TranscriptomicsRNA-seq of primary chondrocytes with ot without aberrant high shear stress treatment
In order to investigate the transcriptome changes underlying aberrant shear stress-induced cartilage pathogenesis, we subjected chondrocytes to Flexcell applinace and the constructed RNA libraries were sequenced on an Illumina HiSeq X Ten platform.
ORGANISM(S): Mus musculus 
2021-12-01 | GSE186501 | GEO
TranscriptomicsComparison of human aortic valve interstitial cells (AVICs) exposed to cyclic stretch to static samples
AVICs were exposed to cyclic stretch to examine the role of mechanical stimuli on gene expression AVICs cultured on collagen 1 coated Bioflex were exposed to 14% stretch at 1 hz or static conditions using a Flexcell-5000
ORGANISM(S): Homo sapiens 
2015-01-09 | GSE47687 | GEO
TranscriptomicsChanges in B10F10 melanoma cells in response to stretch
To study the effects induced by mechanical stretch on cancer cells, B16F10 murine melanoma cells were seeded in Flexcell plates and cultured in static or stretch (15% equibiaxial elongation, 15 cycles/min) for 24 hours. Cells were collected, and RNA isolated and sequenced.
ORGANISM(S): Mus musculus 
2022-02-14 | GSE168499 | GEO
TranscriptomicsEffect of oscillating shear stress on gene expression of endothelial progenitor cells
To investigate the function of oscillating shear stress in the regulation of endothelial progenitor cell (EPCs) differentiation, we used EPCs derived from the umbilical cord blood loaded with OSS for 12h. OSS (±3.5 dynes/cm2, 1 Hz frequency) was loaded using a Flexcell flow STR-4000 parallel plate f...
ORGANISM(S): Homo sapiens 
2022-08-19 | GSE211402 | GEO
GenomicsGenome wide maps of ELK1 bingding sites in HDFs control and mechanic loading groups.
HDFs were cultured for 24 hrs for adhesion and to reach 50-70% confluence before mechanical tension was applied. Cyclic mechanical stretch (CMS) with a 0.5-Hz sinusoidal curve at 10-20% elongation was applied using a Flexcell○RFX-5000TM Tension System during the stretching. Cells were harvested imme...
ORGANISM(S): Homo sapiens 
2019-08-27 | GSE119433 | GEO
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