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ProteomicsJNK-regulated phosphoproteome links synaptic and metabolic pathways to mood regulation
JNKs play critical roles in neuronal damage associated with neurodegenerative disease and inhibitors of JNK1 have shown anxiolytic and anti-depressive effects in mice. In this study, we analyze the phosphoproteomes of hippocampus and nucleus accumbens in mice treated with DJNKI-1, a JNK inhibitor.
ORGANISM(S): Mus musculus (Mouse) 
2025-12-02 | PXD060057 | Pride
ProteomicsRegulators of proteostasis are translationally repressed in fibroblasts from sporadic and LRRK2-G2019S Parkinson’s patients
Here we used non-canonical amino acid labeling and mass-spectrometry based proteomics to perform a quantitative comparison of nascent proteins in fibroblasts from sporadic and G2019S mutation PD patients compared to healthy individuals. We found that several proteins were under-represented among ...
ORGANISM(S): Homo sapiens (Human) 
2022-02-21 | PXD031144 | Pride
Parkinson's disease Protein synthesis 
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