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ProteomicsGlycosylated cyclophellitol-derived activity-based probes and inhibitors for cellulases
Cellulases and related β-1,4-glucanases are essential components of lignocellulose-degrading enzyme mixtures. The detection of β-1,4-glucanase activity typically relies on monitoring the breakdown of purified lignocellulose-derived substrates or synthetic chromogenic substrates, limiting the activit...
ORGANISM(S): Aspergillus niger NRRL3 
2021-09-09 | PXD019930 | Pride
Abpp Activity-based probe Cellulases Cyclophellitol 
ProteomicsDiscovery of a NAPE-PLD inhibitor that modulates emotional behavior in mice
N‑acylethanolamines (NAEs), which include the endocannabinoid anandamide, represent an important family of signaling lipids in the brain. The lack of chemical probes that modulate NAE biosynthesis in living systems hamper the understanding of the biological role of these lipids. Using a high-through...
ORGANISM(S): Homo sapiens (Human) 
2020-05-15 | PXD017586 | Pride
Lipids Drug discovery Endocannabinoids Chemical biology 
ProteomicsActivity-based protein profiling of xylan-degrading glycoside hydrolases in Aspergillus secretomes
Plant polysaccharides represent a virtually unlimited feedstock for the generation of biofuels and other commodities. However, the extraordinary recalcitrance of plant polysaccharides towards breakdown necessitates a continued search for enzymes that degrade these materials efficiently under defined...
ORGANISM(S): Aspergillus Niger (ncbitaxon:5061) 
2019-04-24 | MSV000083714 | MassIVE
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