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ProteomicsMutations in the postsynaptic signaling hub TNIK disrupts neuronal progenitor cells and immature neuronal function in human models of neurodevelopmental disease
Synaptic proteins, in particular those connected in large protein interaction networks at the postsynaptic site of glutamatergic neurons have been associated to a number of neurodevelopmental disorders. While their contribution to disease has been well documented in mature rodent synapses, their rol...
ORGANISM(S): Homo sapiens (Human) 
2024-03-26 | PXD035004 | Pride
Neurodevelopment Hipsc Signaling networks Disease Postsynaptic Signaling 
UnknownSWEET Transporters for the Nourishment of Embryonic Tissues during Maize Germination.
Not available
S-EPMC6826359 | biostudies-literature
UnknownSupporting parents in the Global South: implementation of a faith-based parent program in 12 countries.
Not available
S-EPMC11949733 | biostudies-literature
ProteomicsIntegrated Proteomic and Multi-Omic Characterizations of the Synapse Reveal RNA Processing Factors and Ubiquitin Ligases Associated with Neurodevelopmental Disorders
The molecular composition of the excitatory synapse is incompletely defined due to its dynamic nature across developmental stages and neuronal populations. To address this gap, we apply proteomic mass spectrometry to characterize the synapse in multiple biological models including the fetal human br...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2026-03-09 | PXD020933 | Pride
Induced neurons Synaptic Fetal brain Psd 
UnknownPneumococci remain the main cause of complicated pediatric pneumonia in the post-pandemic era despite extensive pneumococcal vaccine use.
Not available
S-EPMC11587768 | biostudies-literature
UnknownDominance of vaccine serotypes in pediatric invasive pneumococcal infections in Portugal (2012-2015).
Not available
S-EPMC6327022 | biostudies-literature
UnknownSustained increase of paediatric invasive Streptococcus pyogenes infections dominated by M1UK and diverse emm12 isolates, Portugal, September 2022 to May 2023.
Not available
S-EPMC10486195 | biostudies-literature
UnknownClonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2.
Not available
S-EPMC10876565 | biostudies-literature
UnknownDevelopment and validation of a prediction model for 30-day mortality in hospitalised patients with COVID-19: the COVID-19 SEIMC score.
Not available
S-EPMC7908055 | biostudies-literature
UnknownIdentification and validation of clinical phenotypes with prognostic implications in patients admitted to hospital with COVID-19: a multicentre cohort study.
Not available
S-EPMC7906623 | biostudies-literature
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