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TranscriptomicsGene expression profiles of M. tuberculosis constitutively expressing the transcriptional regulator DosR (Rv3133c).
Background: Conflicting results have been reported about the role of the two-component sensor and transcriptional regulator DosS/DosR, controlling the expression of the dormancy DosR regulon, for in vivo virulence of M. tuberculosis. Here, we have used a new approach to further analyze the relevance...
ORGANISM(S): Mycobacterium tuberculosis 
2012-06-12 | E-GEOD-19838 | biostudies-arrayexpress
TranscriptomicsCharacterization of mycobacterial oligopeptide permease system
M. tuberculosis strain 1254 wild type (WT) and its isogenic delta Rv3662c-Rv3665c KO (opp KO) and complemented opp::opp were cultured in vitro, in liquid 7H9 media supplemented with OADC and 0.05% Tween 80, 0.5% glycerol, in a 150 mL volume, contained in roller bottles, incubated at 37oC. Growth wa...
ORGANISM(S): Mycobacterium tuberculosis 
2009-10-06 | E-GEOD-18426 | biostudies-arrayexpress
TranscriptomicsDosR-regulon genes induction in Mycobacterium bovis BCG under aerobic conditions
In this report we demonstrated that under aerobic conditions, Mycobacterium bovis BCG expressing an hsp60-driven second copy of the hypoxia-related transcriptional regulator DosR increased 2-fold or greater the expression of 38 out of the 48 genes belonging to the DosR regulon, including the latency...
ORGANISM(S): Mycobacterium tuberculosis 
2010-05-20 | E-GEOD-21932 | biostudies-arrayexpress
TranscriptomicsComparative genomic profiling of reference strains and selected Canadian field isolates of A. pleuropneumoniae
Actinobacillus pleuropneumoniae, the causative agent of porcine pleuropneumonia, is a highly contagious respiratory pathogen that causes severe losses to the swine industry worldwide. Current commercially-available vaccines are of limited value because they do not induce cross-serovar immunity and d...
ORGANISM(S): Actinobacillus pleuropneumoniae 
2009-01-30 | E-GEOD-14639 | biostudies-arrayexpress
ProteomicsComprehensive evaluation of Ubiquinol-supplemented diet effects in the 3xTg AD mice using MALDI-MSI
Alzheimer's disease (AD) is a chronic neurodegenerative disorder, accounting for up to 75 % of all dementia cases. Although the basis of AD etiology remains unknown, oxidative stress constitutes a major driver given its intimate association, specially at prodromic stages of the disease. In this line...
ORGANISM(S): Mus musculus (Mouse) 
2023-05-10 | PXD037763 | Pride
Mass spectrometry  maldi-imaging  alzheimer disease  coenzyme q10  3xtg-ad mice 
TranscriptomicsIn depth analysis of the interaction of HIV 1 with cellular microRNA biogenesis and effector mechanisms
The question of how HIV 1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4+ PBMCs and...
ORGANISM(S): Homo sapiens 
2014-07-31 | E-GEOD-59944 | biostudies-arrayexpress
UnknownControllability of protein-protein interaction phosphorylation-based networks: Participation of the hub 14-3-3 protein family.
Not available
S-EPMC4872533 | biostudies-literature
MetabolomicsGNPS Fungal extracts from Cenote Tza Itza
Untargeted metabolomics (LC/MS) of fungal extracts (chloroform:methanol) isolated from Cenote Tza Itza in Yucatan, Mexico.
ORGANISM(S): Aspergillus (ncbitaxon:5052) Cladosporium (ncbitaxon:5498) Stachybotrys (ncbitaxon:74721) 
2022-01-17 | MSV000088691 | GNPS
UnknownUrban airborne particle exposure impairs human lung and blood Mycobacterium tuberculosis immunity.
Not available
S-EPMC7162557 | biostudies-literature
UnknownSpodoptera frugiperda (J. E. Smith) Aminopeptidase N1 Is a Functional Receptor of the Bacillus thuringiensis Cry1Ca Toxin.
Not available
S-EPMC6102985 | biostudies-literature
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