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TranscriptomicsTranscription profiling time series of lymphocytes from patients with B chronic lymphocytic leukemia treated with fludarabine to identify a signature of drug resistance
Identification of a signature of resistance to fludarabine in B chronic lymphocytic leukemia patients in vivo
ORGANISM(S): Homo sapiens 
2009-11-28 | E-MTAB-70 | biostudies-arrayexpress
TranscriptomicsChanges in gene expression induced by CDK9 inhibition alone and in combination with fludarabine
Using a transcriptomics approach we explored the mechanism(s) of synergy observed between CDKI-73 and fludarabine in primary CLL cells. The cytotoxic effects of CDKI-73 were associated with transcriptional inhibition of cdk9 target genes including MCL1 and XIAP. In contrast, fludarabine induced the ...
ORGANISM(S): Homo sapiens 
2013-06-25 | E-GEOD-48258 | biostudies-arrayexpress
ProteomicsFludarabine resistance in Mantle cell lymphoma
SILAC analysis of fludarabine resistance in human Mino cells.
ORGANISM(S): Homo sapiens (Human) 
2015-08-03 | PXD002034 | Pride
Silac Mantle cell lymphoma Fludarabine 
TranscriptomicsMicroRNA profiling of blood from human chronic lymphocytic leukemia patients before and after Fludarabine treatment
Molecular profile of Fludarabine refractory and sensitive CLLs
ORGANISM(S): Homo sapiens 
2010-09-01 | E-TABM-824 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human blood from chronic lymphocytic leukemia patients before and after Fludarabine treatment
Transcription profiling of blood from human chronic lymphocytic leukemia patients before and after Fludarabine treatment
ORGANISM(S): Homo sapiens 
2010-09-01 | E-TABM-825 | biostudies-arrayexpress
TranscriptomicsGamma-secretase inhibitor plus fludarabine in CLL
Combination of GSI with fludarabine has a synergistic antileukemic effect in primary NOTCH1-mutated CLL cells We used microarrays to detail the mechanism of synergy of GSI and fludarabine combination in NOTCH1-mutated CLL cells Global RNA expression in CLL primary cells treated with GSI, fludarabin...
ORGANISM(S): Homo sapiens 
2013-09-21 | E-GEOD-51044 | biostudies-arrayexpress
TranscriptomicsGamma-secretase inhibitor plus fludarabine in CLL
Combination of GSI with fludarabine has a synergistic antileukemic effect in primary NOTCH1-mutated CLL cells We used microarrays to detail the mechanism of synergy of GSI and fludarabine combination in NOTCH1-mutated CLL cells
ORGANISM(S): Homo sapiens 
2013-09-21 | GSE51044 | GEO
TranscriptomicsTransposon mutagenesis reveals fludarabine-resistance mechanisms in chronic lymphocytic leukemia
Purpose:To identify resistance mechanisms for the chemotherapeutic drug fludarabine in chronic lymphocytic leukemia (CLL), as innate and acquired resistance to fludarabine-based chemotherapy represents a major challenge for long-term disease control. Methods: We employed piggyBac transposon-mediated...
ORGANISM(S): Homo sapiens 
2016-03-31 | GSE75844 | GEO
TranscriptomicsChanges in gene expression induced by CDK9 inhibition alone and in combination with fludarabine
Using a transcriptomics approach we explored the mechanism(s) of synergy observed between CDKI-73 and fludarabine in primary CLL cells. The cytotoxic effects of CDKI-73 were associated with transcriptional inhibition of cdk9 target genes including MCL1 and XIAP. In contrast, fludarabine induced the ...
ORGANISM(S): Homo sapiens 
2013-06-25 | GSE48258 | GEO
GenomicsGenome Wide Association Studies in ECOG 2903 Trial

The ECOG 2997 trial was a randomized controlled trial for patients with previously untreated CLL comparing fludarabine monotherapy to the combination of fludarabine and cyclophosphamide. The initial clinical findings of this study were published in the Journal of Clinical Oncology in 2007 (JCO 25...

phs000621.v1.p1 | EGA
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