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ProteomicsProteomic analysis of integrin-associated adhesion complexes isolated from cells treated with DMSO or FAK inhibitor
Human foreskin fibroblast cells were spread on fibronectin (FN) for 1 h and treated with DMSO or FAK inhibitor (3 uM, AZ13256675 (termed AZ675 for short)) for 1 h. Integrin-associated adhesion complexes isolated from these cells were analysed by mass spectrometry to determine changes in adhesion com...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-08-23 | MSV000080089 | MassIVE
TranscriptomicssiRNA profiling if human MCF-7 cell line to investigate the role of FAK, dominant-negative FAK, FAK-CD and FAKsiRNA in MCF-7 human breast cancer cell tumorigenesis
Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase that plays an important role in proliferation, motility, adhesion, invasion, angiogenesis, and survival signaling. Focal adhesion kinase has been shown to be overexpressed in many types of tumors, including breast cancer at early stages o...
ORGANISM(S): Homo sapiens 
2009-08-22 | E-GEOD-11581 | biostudies-arrayexpress
GenomicsTranscriptional Rewiring of BET Inhibitor Treated Ewing Sarcoma Cells Augments their Dependency on Focal Adhesion Kinase
Transcriptional Rewiring of BET Inhibitor Treated Ewing Sarcoma Cells Augments their Dependency on Focal Adhesion Kinase
PRJNA1274418 | ENA
TranscriptomicsTargeting Focal Adhesion Kinase Renders Pancreatic Cancers Responsive to Checkpoint Immunotherapy
Immunotherapeutics represent highly promising agents with the potential to improve patient outcomes in a variety of cancer types. Unfortunately, single-agent immunotherapy has achieved limited clinical benefit to date in patients suffering from pancreatic ductal adenocarcinoma (PDAC). This may be du...
ORGANISM(S): Mus musculus 
2015-11-21 | E-GEOD-75233 | biostudies-arrayexpress
ProteomicsProteomic analysis of integrin-associated adhesion complexes isolated from cells treated with DMSO or FAK inhibitor
Human foreskin fibroblast cells were spread on fibronectin (FN) for 1 h and treated with DMSO or FAK inhibitor (3 uM, AZ13256675 (termed AZ675 for short)) for 1 h. Integrin-associated adhesion complexes isolated from these cells were analysed by mass spectrometry to determine changes in adhesion com...
ORGANISM(S): Homo sapiens (Human) 
2016-02-02 | PXD002720 | Pride
Proteomics Ms Adhesion Focal adhesion kinase (fak) Integrin 
ProteomicsProteomic characterisation of microtubule-dependent modulation of adhesion complexes
Investigating the effect of microtubule disruption by nocodazole treatment on isolated adhesion complexes.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-07-19 | MSV000079926 | MassIVE
TranscriptomicsShp2 Signaling Suppresses Senescence in PyMT-induced Mammary Gland Cancer in Mice [Mouse430A_2 array]
In this study, we have used techniques from cell biology, biochemistry, and genetics to investigate the role of the tyrosine phosphatase Shp2 in tumor cells of MMTV-PyMT mouse mammary glands. Genetic ablation or pharmacological inhibition of Shp2 induces senescence, as determined by the activation o...
ORGANISM(S): Mus musculus 
2015-03-06 | E-GEOD-50516 | biostudies-arrayexpress
GenomicsControl of Focal Adhesion Kinase Activation by RUNX1-regulated miRNAs in high-risk AML
We recently described a 16-gene expression signature for improved risk stratification of acute myeloid leukemia (AML) patients called the AML Prognostic Score (APS). A subset of APS high-risk AML patients showed increased levels of focal adhesion kinase (FAK), encoded by the Protein Tyrosine Kinase ...
EGAS00001006491 | EGA
TranscriptomicsEarly Dysregulation of Cell Adhesion and Extracellular Matrix Pathways in Breast Cancer Progression
Proliferative breast lesions, such as simple ductal hyperplasia (SH) and atypical ductal hyperplasia (ADH), are candidate precursors to ductal carcinoma in situ (DCIS) and invasive cancer. To better understand their relationship to more advanced disease, we used microdissection and DNA microarrays t...
ORGANISM(S): Homo sapiens 
2009-09-08 | E-GEOD-16873 | biostudies-arrayexpress
TranscriptomicsDeregulation of focal adhesion pathway mediated by miR-659-3p is implicated in bone marrow infiltration of stage M neuroblastoma patients
Presence of BM-infiltrating neuroblastoma (NB) cells occurs in about 50% of patients affected by this peculiar pediatric cancer. Children aged more than 18 months at diagnosis with metastatic NB are high-risk patients with 25-30% overall survival at 5 years, despite multimodal aggressive therapy. Li...
ORGANISM(S): Homo sapiens 
2015-04-20 | E-GEOD-65153 | biostudies-arrayexpress
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