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TranscriptomicsManipulation of Temperature and Photoperiod Identifies Molecular Networks Associated with the Para- to Endo-dormant Transition in Leafy Spurge Crown Buds
Leafy spurge is a model for studying well-defined phases of dormancy in underground adventitious buds (UABs) of herbaceous perennial weeds, which is a primary factor allowing many invasive perennial weeds to escape conventional control measures. A 12-week ramp down in both temperature (27M-BM-0C M-b...
ORGANISM(S): Euphorbia esula 
2012-12-31 | E-GEOD-37477 | biostudies-arrayexpress
TranscriptomicsGlobal analysis of the RNA-protein interaction and RNA secondary structure landscapes of the Arabidopsis nucleus
Post-transcriptional regulation in eukaryotes requires cis- and trans-acting features and factors including RNA secondary structure, and RNA-binding proteins (RBPs). However, a comprehensive view of the structural and RBP interaction landscape of RNAs in the nucleus has yet to be compiled for any or...
ORGANISM(S): Arabidopsis thaliana 
2014-12-16 | E-GEOD-58974 | biostudies-arrayexpress
TranscriptomicsEnhanced energetic state and protection from oxidative stress in human myoblasts overexpressing BMI1
The Polycomb group gene BMI1 is essential for efficient muscle regeneration in a mouse model of Duchenne Muscular Dystrophy and its enhanced expression in adult skeletal muscle satellite cells ameliorates the muscle strength in this model. In this experiment, we investigated the impact of mild BMI1 ...
ORGANISM(S): Homo sapiens 
2017-12-15 | E-MTAB-5846 | biostudies-arrayexpress
TranscriptomicsGlycan changes caused by insulin-deficient diabetes in the mouse liver
To determine the effect of insulin deficiency on global changes to expression of glycan related genes in the liver. See: Joseph R. Bishop,‡ Erin Foley,‡§ Roger Lawrence,‡ and Jeffrey D. Esko‡1 (2010) Insulin-dependent Diabetes Mellitus in Mice Does Not Alter Liver Heparan Sulfate* J Biol Chem. 2010 ...
ORGANISM(S): Mus musculus 
2011-09-07 | E-GEOD-31989 | biostudies-arrayexpress
TranscriptomicsExpression data in whole Arabidopsis seedlings after treatment with the herbicide dicamba
Dicamba is an auxin-like herbicide that can stimulate the production of ethylene and ABA biosynthesis. The subsequent stomatal closure and build-up of reactive oxygen species is hypothesized to contribute to plant death. In order to further understand the herbicide dicamba's mode of action at the m...
ORGANISM(S): Arabidopsis thaliana 
2010-12-10 | E-GEOD-24052 | biostudies-arrayexpress
TranscriptomicsLow temperatures impact dormancy status, flowering competence, and transcript profiles in crown buds of leafy spurge.
Leafy spurge (Euphorbia esula) is an herbaceous perennial weed that produces vegetatively from an abundance of underground adventitious buds. The objectives of this study were to determine how mimicking natural seasonal conditions (photoperiod and temperature) under controlled environmental conditio...
ORGANISM(S): Euphorbia esula 
2010-05-19 | E-GEOD-19217 | biostudies-arrayexpress
TranscriptomicsTranscriptomic analysis of TLR4 pathways in a murine model of chronic pulmonary inflammation and carcinogenesis
Toll like receptor 4 (TLR4), an innate immunity gene, is involved in responses to several pulmonary agonists including endotoxin (LPS; Poltorak et al.,1998), ozone (O3 ,Kleeberger et. al., 2001), Pseudomonas aeruginosa (Faure et al, 2004), and hyperoxia (Zhang et al, 2005). TLR4 appears to partially...
ORGANISM(S): Mus musculus 
2009-12-12 | E-GEOD-8504 | biostudies-arrayexpress
MetabolomicsProfiling the metabolome of uterine fluid for early detection of ovarian cancer

Ovarian cancer (OC) causes high mortality in women because of ineffective biomarkers for early diagnosis. Here, we perform metabolomics analysis on an initial training set of uterine fluid from 96 gynecological patients. A seven-metabolite-marker panel consisting of vanillylmandelic acid, norepin...

2023-03-06 | MTBLS4861 | MetaboLights
TranscriptomicsmRNA immunoprecipitated with CUGBP1 in C2C12
Dramatic changes in gene expression occur in response to extracellular stimuli and during differentiation. Although transcriptional effects are important, alterations in mRNA decay also play a major role in achieving rapid and massive changes in mRNA abundance. Moreover, just as transcription fact...
ORGANISM(S): Mus musculus 
2010-07-08 | E-GEOD-21235 | biostudies-arrayexpress
TranscriptomicsEffect of brain death on gene expression in liver from rhesus macaque
The majority of transplanted organs are recovered from deceased donors after brain death (BD). BD has been hypothesized to compromise organ quality in part from the activation of systemic inflammation. The objective of this study was to characterize the immune response induced by BD in a well con...
ORGANISM(S): Macaca mulatta 
2012-06-27 | E-GEOD-22624 | biostudies-arrayexpress
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