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UnknownFolliculin Interacting Protein 1 Maintains Metabolic Homeostasis during B Cell Development by Modulating AMPK, mTORC1, and TFE3.
Not available
S-EPMC6864314 | biostudies-literature
UnknownAbsent B cells, agammaglobulinemia, and hypertrophic cardiomyopathy in folliculin-interacting protein 1 deficiency.
Not available
S-EPMC7845007 | biostudies-literature
UnknownAction and therapeutic targets of folliculin interacting protein 1: a novel signaling mechanism in redox regulation.
Not available
S-EPMC11936992 | biostudies-literature
ProteomicsPost-translational Regulation of FNIP1: a Rheostat for the Molecular Chaperone Hsp90
The molecular chaperone Hsp90 stabilizes and activates client proteins. Co-chaperones and post-translational modifications tightly regulate Hsp90 function and consequently lead to activation of clients. However, it is unclear whether this process occurs abruptly or gradually in the cellular context....
ORGANISM(S): Homo sapiens (Human) 
2019-01-31 | PXD012229 | Pride
Heat shock protein-90 (hsp90) Folliculin-interacting protein-1 O-glcnacylation Co-chaperone Fnip1 Pp5 Serine/threonine protein phosphatase-5 
TranscriptomicsThe Folliculin-Fnip1 pathway deleted in human Birt-Hogg-Dube syndrome is required for B cell development.
Birt-Hogg-Dube (BHD) syndrome is an autosomal dominant disorder characterized by hamartomas of skin follicles, cystic lung disease, and renal neoplasia. Affected individuals carry heterozygous mutations in Folliculin (FLCN), a tumor suppressor gene that becomes biallelically inactivated in kidney t...
ORGANISM(S): Mus musculus 
2012-06-16 | E-GEOD-38741 | biostudies-arrayexpress
TranscriptomicsThe Folliculin-Fnip1 pathway deleted in human Birt-Hogg-Dube syndrome is required for B cell development.
Birt-Hogg-Dube (BHD) syndrome is an autosomal dominant disorder characterized by hamartomas of skin follicles, cystic lung disease, and renal neoplasia. Affected individuals carry heterozygous mutations in Folliculin (FLCN), a tumor suppressor gene that becomes biallelically inactivated in kidney tu...
ORGANISM(S): Mus musculus 
2012-06-16 | GSE38741 | GEO
TranscriptomicsRNAseq analysis of adipose tissue transcriptomes from wild-type and FNIP1 adipocyte specific knockout (FNIP1-AKO) mice
Activation of thermogenesis in brown and beige adipocytes upon activation by external stimuli burns fuel energy as heat. Owing to its remarkable benefits on metabolic health and its demonstrated presence in adult humans, beige adipocytes holds great promise to combat obesity and metabolic diseases. ...
ORGANISM(S): Mus musculus 
2022-02-26 | GSE185067 | GEO
UnknownDirect regulation of FNIP1 and FNIP2 by MEF2 sustains MTORC1 activation and tumor progression in pancreatic cancer.
Not available
S-EPMC10936626 | biostudies-literature
UnknownInduction of lysosomal and mitochondrial biogenesis by AMPK phosphorylation of FNIP1.
Not available
S-EPMC10794112 | biostudies-literature
UnknownMutation of Fnip1 is associated with B-cell deficiency, cardiomyopathy, and elevated AMPK activity.
Not available
S-EPMC4932993 | biostudies-literature
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