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TranscriptomicsGene expression profiling classifies lung squamous cell carcinomas with N1 positive lymph nodes
Using gene expression microarrays, we tested whether lung SCCs that have metastasised to loco-regional lymph nodes (N1/2m) are different to those that directly invade and involve local nodes (N1d). Using 22,323 element microarrays, a non-parametric test identified 126 genes/transcripts that discrimi...
ORGANISM(S): Homo sapiens 
2007-05-01 | E-GEOD-5828 | biostudies-arrayexpress
TranscriptomicsExpression profiling defines a recurrence signature in lung squamous cell carcinoma
Lung cancer remains the leading cause of cancer death worldwide. Overall 5-year survival is about 10-15% and despite curative intent surgery, treatment failure is primarily due to recurrent disease. Conventional prognostic markers are unable to determine which patients with completely resected disea...
ORGANISM(S): Homo sapiens 
2010-07-01 | E-GEOD-5123 | biostudies-arrayexpress
TranscriptomicsADAM-28: A potential oncogene involved in asbestos-related lung adenocarcinomas
To identify gene expression biomarkers associated with asbestos-related lung adenocarcinoma, we analyzed primary tumour gene expression for a total of 36 primary lung adenocarcinomas on 22,323 element microarrays, comparing 12 patients with lung asbestos body counts above levels associated with urba...
ORGANISM(S): Homo sapiens 
2010-05-28 | E-GEOD-20875 | biostudies-arrayexpress
TranscriptomicsArray-Comparative Genomic Hybridization Reveals Loss of SOCS6 is Associated with Poor Prognosis in Primary Lung Squamous Cell Carcinoma
Primary tumor recurrence occurs commonly after surgical resection of lung squamous cell carcinoma (SCC). The aim of this study was to identify genes involved in recurrence in lung squamous cell carcinoma patients. Array comparative genomic hybridization (aCGH) was performed on DNA extracted from tum...
ORGANISM(S): Homo sapiens 
2011-12-25 | E-GEOD-32058 | biostudies-arrayexpress
TranscriptomicsDevelopment of microRNA expression signature for emphysema in COPD patients
To define the role of microRNAs and their mRNA targets in emphysema severity in COPD patients. We performed Agilent human miRNA oligo arrays (8x15K array, Part No. G4470A, Agilent Technologies) based on miRBase V9.1 on lung tissues from 9 mild and 20 moderate emphysema lungs obtained from patients u...
ORGANISM(S): Homo sapiens 
2012-05-31 | E-GEOD-33336 | biostudies-arrayexpress
TranscriptomicsRegulation of nucleosome landscape and transcription factor binding at enhancers by BRG1
Enhancers of transcription activate transcription via binding of sequence-specific transcription factors to their target sites in chromatin. In this report, we identify GATA1-bound enhancers genome-wide and find a global reorganization of the nucleosomes at these enhancers during differentiation of ...
ORGANISM(S): Homo sapiens 
2011-07-01 | E-GEOD-26501 | biostudies-arrayexpress
UnknownA Recurrent De Novo Variant in NACC1 Causes a Syndrome Characterized by Infantile Epilepsy, Cataracts, and Profound Developmental Delay.
Not available
S-EPMC5294886 | biostudies-literature
UnknownInsights into the accuracy of social scientists' forecasts of societal change.
Not available
S-EPMC10192018 | biostudies-literature
UnknownThe Immune Landscape of Cancer.
Not available
S-EPMC5982584 | biostudies-literature
UnknownFatal and Nonfatal Events Within 14 days After Early, Intensive Mobilization Poststroke.
Not available
S-EPMC8055346 | biostudies-literature
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